Song Cao, PhD

Song Cao, PhD

Oncology

Primary Academic Title

Assistant Professor, Division of Oncology, Washington University School of Medicine

Research Interest

My research interests include cancer virology, cancer genomics, and cancer proteomics. I have a deep understanding of various omics data types, including DNA-Seq, RNA-Seq, scRNA-Seq, and mass spectrometry data. I have led the development of multiple bioinformatics tools and pipelines, such as VirusScan for virus detection from NGS data, Misplice tool for detecting splice-site-creating mutations, somaticwrapper and germlinewrapper pipelines for calling somatic and germline variants, and among others. My long-term goal is to discover rational therapeutic targets that meaningfully impact the lives of cancer patients. For instance, by working with CPTAC members, I uncovered high PTPN11 Y62 phosphorylation in EGFR-altered brain and lung tumors.

Education

  • 2003: PhD, Zhejiang University

Training

  • 2003 - 2008: Postdoctoral Fellow, Department of Physics , University of Missouri-Columbia, Columbia, MO
  • 2008 - 2011: Research Associate, Department of Physics , University of Missouri-Columbia, Columbia, MO

Selected Research Publications

Multi-scale signaling and tumor evolution in high-grade gliomas.
  • Liu J, Cao S, Imbach KJ, [...] Ding L
  • Cancer Cell 2024
Epigenetic regulation during cancer transitions across 11 tumour types.
  • Terekhanova NV, Karpova A, Liang WW, [...] Cao S, [...] Ding L
  • Nature 2023
Pan-cancer proteogenomics connects oncogenic drivers to functional states.
  • Li Y, Porta-Pardo E, Tokheim C, [...] Cao S, [...] Ding L
  • Cell 2023
Proteogenomic data and resources for pan-cancer analysis.
  • Li Y, Dou Y, Da Veiga Leprevost F, [...] Cao S, [...] Payne SH
  • Cancer Cell 2023
Single-Cell Discovery and Multiomic Characterization of Therapeutic Targets in Multiple Myeloma.
  • Yao L, Wang JT, Jayasinghe RG, [...] Cao S, [...] DiPersio JF
  • Cancer Res 2023
LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint.
  • McKerrow W, Wang X, Mendez-Dorantes C, [...] Cao S, [...] Fenyö D
  • Proc Natl Acad Sci USA 2022

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