Aaron  DiAntonio, MD, PhD

Aaron DiAntonio, MD, PhD

Primary Academic Title

Professor of Developmental Biology, Washington University School of Medicine

Research Interest

Synapses change as neuronal circuits develop and are modified by experience. We study the molecular mechanisms that underlie the maturation of synaptic structure and function during development. We use the Drosophila neuromuscular junction as a model system because of the ease with which genetic, molecular, anatomical and electrophysiological techniques can be combined.


  • 1989: MPhil, biochemistry, Cambridge University, Cambridge, England
  • 1995: MD/PhD, physiology, Stanford University, Stanford, Calif.


  • 1995 - 1999: Postdoctoral fellow, developmental biology, University of California, Berkeley

Selected Research Publications

Macrophage depletion blocks congenital SARM1-dependent neuropathy.
  • Dingwall CB, Strickland A, Yum SW, [...] DiAntonio A, Milbrandt J
  • J Clin Invest 2022
Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity.
  • Brace EJ, Essuman K, Mao X, [...] DiAntonio A
  • PLoS Genet 2022
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
  • Shi Y, Kerry PS, Nanson JD, [...] DiAntonio A, [...] Ve T
  • Mol Cell 2022
Live imaging reveals the cellular events downstream of SARM1 activation.
  • Ko KW, Devault L, Sasaki Y, Milbrandt J, DiAntonio A
  • Elife 2021

View All Publications