John Edwards, PhD

Primary Academic Title

Associate Professor of Medicine, Center for Pharmacogenomics, Washington University School of Medicine

Research Interest

New experimental and computational tools to understand the cooperation between methylation and other genomic changes that contribute to processes including tumorigenesis and therapy resistance. Understanding how hypomethylation remodels the transcriptome and affects genomic instability.

Education

2001: MS, chemical engineering and applied chemistry, Columbia University, New York
2003: PhD, chemical engineering (genomics), Columbia University

Training

2003 - 2006: Postdoctoral researcher, Columbia University, New York

Selected Research Publications

Breast Cancer Mutations HER2V777L and PIK3CAH1047R Activate the p21-CDK4/6-Cyclin D1 Axis to Drive Tumorigenesis and Drug Resistance.

Cheng X, Sun Y, Highkin M, [...] Edwards JR, Bose R
Cancer Res 2023

Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia.

Desai PM, Brown J, Gill S, [...] Edwards J, [...] Ravandi F
J Clin Oncol 2021

Determining subpopulation methylation profiles from bisulfite sequencing data of heterogeneous samples using DXM.

Fong J, Gardner JR, Andrews JM, [...] Edwards JR
Nucleic Acids Res 2021

View All Publications

Siteman Cancer Center ranked No. 10 among U.S. cancer centers

Diversity, Equity & Inclusion at Siteman

How Siteman is leading the way in personalized brain tumor treatment

Siteman Cancer Center expands proton therapy treatment

Siteman explains what every woman should know about endometrial cancer risk, symptoms and screening

Immunity boosting treatment enhances CAR-T cell therapy for blood cancers

$5.3 million grant supports research into lung cancer recurrence

Couple honors physician with gift for distinguished professorship

Siteman Cancer Center ranked No. 10 among U.S. cancer centers

Siteman Cancer Center ranked No. 10 among U.S. cancer centers

Diversity, Equity & Inclusion at Siteman

How Siteman is leading the way in personalized brain tumor treatment

Treatment
Clinical
How Siteman is leading the way in personalized brain tumor treatment
If you or a loved one have recently been diagnosed with a brain tumor, you likely feel a great deal of fear and have many questions. The brain is the epicenter of who we are,...
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How Siteman is leading the way in personalized brain tumor treatment

Cancer Types

The Siteman Approach

Specialized Programs

Siteman Cancer Center expands proton therapy treatment

Siteman Cancer Center expands proton therapy treatment

Siteman explains what every woman should know about endometrial cancer risk, symptoms and screening

Siteman explains what every woman should know about endometrial cancer risk, symptoms and screening

Immunity boosting treatment enhances CAR-T cell therapy for blood cancers

Immunity boosting treatment enhances CAR-T cell therapy for blood cancers

$5.3 million grant supports research into lung cancer recurrence

$5.3 million grant supports research into lung cancer recurrence

Couple honors physician with gift for distinguished professorship

Couple honors physician with gift for distinguished professorship

John Edwards, PhD

Primary Academic Title

Research Interest

Education

Training

Selected Research Publications