Studying how B and T cells assemble an enormous diversity of antigen receptor genes. This process, called VDJ recombination, is essential for immune function and recognition of myriad pathogens to which we are exposed. However, when this genetic assembly process goes awry, it can produce chromosomal translocations that underlie nearly all types of leukemias and lymphomas. Specifically, we study how VDJ recombination is properly targeted via crosstalk between genetic and epigenetic mechanisms.
- 1983: MS, Chemistry, Columbia University, New York
- 1986: MPhil, Chemistry, Columbia University
- 1987: PhD, Chemistry, Columbia University
- 1987 - 1991: Postdoctoral fellow, immunology, Columbia University, New York
- 1991 - 1993: Postdoctoral fellow, immunology, Harvard University, Boston
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