Sofia Origanti, PhD

Sofia Origanti, PhD

Primary Academic Title

Assistant Professor of Biology, Saint Louis University

Research Interest

Translational control of normal and diseased states, the pervasiveness of translational control is evident in the genesis and progression of several diseases including cancer that are a consequence of deregulated protein synthesis

Education

  • 2007: PhD, cell and molecular biology, Penn State University, Hersey, Penn.

Training

  • 2007 - 2012: Postdoctoral associate, Washington University, St. Louis

Selected Research Publications

Mechanism of RPA phosphocode priming and tuning by Cdk1/Wee1 signaling circuit.
  • Roshan P, Kaushik V, Mistry A, [...] Origanti S
  • bioRxiv 2025
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation.
  • Chadda R, Kaushik V, Ahmad IM, [...] Origanti S, Antony E
  • Nucleic Acids Res 2024
An Aurora B-RPA signaling axis secures chromosome segregation fidelity.
  • Roshan P, Kuppa S, Mattice JR, [...] Origanti S
  • Nat Commun 2023
Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.
  • Elliff J, Biswas A, Roshan P, [...] Origanti S
  • Nucleic Acids Res 2023