Amanda Smith, PhD

Amanda Smith, PhD

Primary Academic Title

Instructor of Medicine, Division of Oncology, Washington University School of Medicine

Research Interest

Acute myeloid leukemia pathogenesis, syndromes characterized by dysregulated cancer genes


  • 2013: PhD, medical biochemistry, University of Newcastle, Australia


  • 2013 - 2016: Research associate, University of Queensland, Australia
  • 2016 - 2019: Research assocaite, Washington University, St. Louis

Selected Research Publications

Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
  • Smith AM, LaValle TA, Shinawi M, [...] Ley TJ
  • Nat Commun 2021
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
  • Chen DY, Ferguson IM, Braun KA, [...] Smith AM, [...] Ley TJ
  • Proc Natl Acad Sci USA 2021