John-Stephen Taylor, PhD

Primary Academic Title

Professor of Chemistry, Washington University School of Medicine

Research Interest

We are trying to unravel the molecular mechanisms by which sunlight causes the mutations that lead to skin cancer by a combined synthetic, physical and biological approach. In addition, we are studying the biological consequences of DNA strand breaks induced by ionization radiation. We are also developing a completely new approach to chemotherapy that makes use of a cancer-specific mRNA to trigger the release of a cytotoxic agent.

Education

1981: PhD, organic chemistry, Columbia University, New York

Training

1981 - 1983: Postdoctoral fellow, bio-organic chemistry, California Institute of Technology, Pasadena

Selected Research Publications

Post- and Pre-Radiolabeling Assays for anti Thymidine Cyclobutane Dimers as Intrinsic Photoprobes of Various Types of G-Quadruplexes, Reverse Hoogsteen Hairpins, and Other Non-B DNA Structures.

Gutierrez-Bayona NE, Scruggs SS, Yang HC, [...] Taylor JS
Biochemistry 2023

Adjacent and Nonadjacent Dipyrimidine Photoproducts as Intrinsic Probes of DNA Secondary and Tertiary Structure†.

Taylor JS
Photochem Photobiol 2023

Ability of the Putative Decomposition Products of 2,3-dioxetanes of Indoles to Photosensitize Cyclobutane Pyrimidine Dimer (CPD) Formation and its Implications for the "Dark" (Chemisensitized) Pathway to CPDs in Melanocytes†.

Wang Y, Cacchillo EM, Niedzwiedzki DM, Taylor JS
Photochem Photobiol 2022

The effect of flanking bases on direct and triplet sensitized cyclobutane pyrimidine dimer formation in DNA depends on the dipyrimidine, wavelength and the photosensitizer.

Lu C, Gutierrez-Bayona NE, Taylor JS
Nucleic Acids Res 2021

View All Publications

Siteman Cancer Center ranked No. 10 among U.S. cancer centers

Diversity, Equity & Inclusion at Siteman

How Siteman is leading the way in personalized brain tumor treatment

Siteman Cancer Center expands proton therapy treatment

Siteman explains what every woman should know about endometrial cancer risk, symptoms and screening

Immunity boosting treatment enhances CAR-T cell therapy for blood cancers

$5.3 million grant supports research into lung cancer recurrence

Couple honors physician with gift for distinguished professorship

Siteman Cancer Center ranked No. 10 among U.S. cancer centers

Siteman Cancer Center ranked No. 10 among U.S. cancer centers

Diversity, Equity & Inclusion at Siteman

How Siteman is leading the way in personalized brain tumor treatment

Treatment
Clinical
How Siteman is leading the way in personalized brain tumor treatment
If you or a loved one have recently been diagnosed with a brain tumor, you likely feel a great deal of fear and have many questions. The brain is the epicenter of who we are,...
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How Siteman is leading the way in personalized brain tumor treatment

Cancer Types

The Siteman Approach

Specialized Programs

Siteman Cancer Center expands proton therapy treatment

Siteman Cancer Center expands proton therapy treatment

Siteman explains what every woman should know about endometrial cancer risk, symptoms and screening

Siteman explains what every woman should know about endometrial cancer risk, symptoms and screening

Immunity boosting treatment enhances CAR-T cell therapy for blood cancers

Immunity boosting treatment enhances CAR-T cell therapy for blood cancers

$5.3 million grant supports research into lung cancer recurrence

$5.3 million grant supports research into lung cancer recurrence

Couple honors physician with gift for distinguished professorship

Couple honors physician with gift for distinguished professorship

John-Stephen Taylor, PhD

Primary Academic Title

Research Interest

Education

Training

Selected Research Publications