John Welch, MD, PhD

Research Interest

Understanding pathways of normal myeloid development and leukemic dysregulation of myeloid self-renewal programs. As a model system, I have focused on acute promyelocytic leukemia, which is associated with the t(15;17) translocation and the PML-RARA fusion oncoprotein. Initial exposure of hematopoietic cells to PML-RARA leads to inappropriate self-renewal but not myeloproliferation. We are now focusing on understanding programs that lead to dysregulated self-renewal by PML-RARA, especially retinoid receptor-dependent pathways.

Education

• 2002: PhD, biomedical sciences, University of California, San Diego
• 2004: MD, University of California, San Diego

Training

• 2004 - 2006: Intern and resident, internal medicine, Washington University, St. Louis
• 2006 - 2010: Fellow, hematology and oncology, Washington University

Journal Articles

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