blood-brain barrier disruption
Pronunciation: (blud-brayn BAYR-ee-er dis-RUP-shun)
The use of drugs to create openings between cells in the blood-brain barrier. The blood-brain barrier is a protective network of blood vessels and tissue that protects the brain from harmful substances, but can also prevent anticancer drugs from reaching the brain. Once the barrier is opened, anticancer drugs may be infused into an artery that goes to the brain, in order to treat brain tumors. Also called BBBD.
Source: NCI Dictionary of Cancer Terms2003-12-23 Date last modified: 2007-01-18