Clark level IV skin cancer
Pronunciation: (klark LEH-vul … skin KAN-ser)
Skin cancer that has spread down into the reticular dermis (the thick bottom layer of the dermis).
Source: NCI Dictionary of Cancer Terms
Caption: Clark levels of skin cancer. In Clark Level I, the cancer is in the epidermis only. In Clark Level II, the cancer has begun to spread into the papillary dermis (upper layer of the dermis). In Clark Level III, the cancer has spread through the papillary dermis into the papillary-reticular dermal interface but not into the reticular dermis (lower layer of the dermis). In Clark Level IV, the cancer has spread into the reticular dermis. In Clark Level V, the cancer has spread into the subcutaneous tissue.2009-01-28 Date last modified: 2010-11-18