NEDD8-activating enzyme inhibitor

Definition of NEDD8-activating enzyme inhibitor

NEDD8-activating enzyme inhibitor (… AK-tih-vay-ting EN-zime in-HIH-bih-ter): A substance that blocks an enzyme called NEDD8-activating enzyme (NAE). NAE is involved in important cell functions, such as cell division. Blocking NAE may help keep cancer cells from growing and may kill them. Some NEDD8-activating enzyme inhibitors are being studied in the treatment of cancer. They are a type of targeted therapy. Also called NAE inhibitor.

Source: NCI Dictionary of Cancer Terms