Clinical Trials

201509033

Computer-based Neurocognitive Assessment in Children with Central Nervous System Tumors Receiving Proton Beam Radiation Therapy Phase N/A Principal Investigator Perkins, Stephanie Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201604115

A phase I/II dose-escalation and dose-expansion study of disulfiram/copper with concurrent radiation therapy and temozolomide in patients with newly diagnosed glioblastoma Phase I/II Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more…

201707047

Phase III Trial of Observation vs Irradiation for a Gross Totally Resected Grade II Meningioma Phase III Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201709026

A Phase II Randomized Trial of Proton vs Photon Therapy (IMRT) for Cognitive Preservation in Patients with IDH Mutant, Low to Intermediate Grade Gliomas Phase II Principal Investigator Huang, Jiayi Disease Site Brain and Nervous…

201709055

Phase II Trial of BRAF/MEK Inhibitors in Papillary Craniopharyngiomas Phase II Principal Investigator Johanns, Tanner Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201808111

Protocol CCTG CE.7, A Phase III Trial of Stereotactic Radiosurgery Compared with Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5-15 Brain Metastases Phase III Principal Investigator Huang, Jiayi Disease Site Anus; Bones and Joints;…

201810185

Effect of rhIL-7-hyFc on increasing lymphocyte counts in patients with newly diagnosed non-severe lymphopenic gliomas following radiation and temozolomide Phase I/II Principal Investigator Chheda, Milan Disease Site Brain and Nervous System Learn more about this…

201901009

A Phase I/II Study of Nivolumab plus or minus Ipilimumab in Combination with Multi-fraction Stereotactic Radiosurgery for Recurrent High-grade Radiation-relapsed Meningioma Phase I/II Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more…

201903023

Pilot Study of Same-session MR-only Simulation and Treatment with Stereotactic MRI-guided Adaptive Radiotherapy (SMART) for Oligometastases of the Spine Phase N/A Principal Investigator Henke, Lauren Disease Site Anus; Bones and Joints; Brain and Nervous System;…

201905095

GBM AGILE Phase II/III (Cancer Control) Principal Investigator Ansstas, George Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201908018

Mapping Draining Lymph Nodes in CNS Malignancies Phase I Principal Investigator Johanns, Tanner Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201911203

Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease Phase III (Cancer Prevention) Principal Investigator Abraham, Christopher Disease Site Anus; Bones and Joints; Breast;…

202003050

Safety and efficacy study of retifanlimab and epacadostat in combination with radiation and bevacizumab in patients with recurrent gliomas Phase II Principal Investigator Chheda, Milan Disease Site Brain and Nervous System Learn more about this…

202003064

Phase I/II Study of Pamiparib (BGB-290) with Temozolomide in Recurrent Gliomas with IDH1/2 Mutations Phase I/II Principal Investigator Chheda, Milan Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

202003072

A Pilot Study to Assess the Safety, Feasibility, and Immunogenicity of a Neoantigen-based Personalized DNA Vaccine in Patients with Newly Diagnosed, Unmethylated Glioblastoma Phase I Principal Investigator Johanns, Tanner Disease Site Brain and Nervous System…

202009128

A Phase 1, Open-Label, Multicenter, Dose Escalation and Expansion Study of PRT811 in Subjects with Advanced Solid Tumors, CNS Lymphoma, and Recurrent High-Grade Gliomas Phase I (Cancer Control) Principal Investigator Johanns, Tanner Disease Site Anus;…

202011112

Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients with Recurrent Select Rare CNS Cancers Phase II Principal Investigator Chheda, Milan Disease Site Brain and Nervous System Learn more about this study at:…

202012017

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1 Phase III (Cancer Control) Principal Investigator…

202012180

A PHASE II STUDY OF CHECKPOINT BLOCKADE IMMUNOTHERAPY IN PATIENTS WITH SOMATICALLY HYPERMUTATED RECURRENT GLIOBLASTOMA Phase II Principal Investigator Johanns, Tanner Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201011809

BIRN Resources Facilitate the Personalization of Malignant Brain Tumors this study is also known as CONDR(COmprehensive Neuro oncology Data Repository) Phase N/A Principal Investigator Marcus, Daniel Disease Site Brain and Nervous System

201111001

Analysis of Histological, Genomic, Molecular, and Clinical Factors in CNS Cancer: The Neuro-Oncology Group

201604115

A phase I/II dose-escalation and dose-expansion study of disulfiram/copper with concurrent radiation therapy and temozolomide in patients with newly diagnosed glioblastoma Phase I/II Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more…

201707047

Phase III Trial of Observation vs Irradiation for a Gross Totally Resected Grade II Meningioma Phase III Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201709026

A Phase II Randomized Trial of Proton vs Photon Therapy (IMRT) for Cognitive Preservation in Patients with IDH Mutant, Low to Intermediate Grade Gliomas Phase II Principal Investigator Huang, Jiayi Disease Site Brain and Nervous…

201709055

Phase II Trial of BRAF/MEK Inhibitors in Papillary Craniopharyngiomas Phase II Principal Investigator Johanns, Tanner Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201808111

Protocol CCTG CE.7, A Phase III Trial of Stereotactic Radiosurgery Compared with Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5-15 Brain Metastases Phase III Principal Investigator Huang, Jiayi Disease Site Anus; Bones and Joints;…

201810185

Effect of rhIL-7-hyFc on increasing lymphocyte counts in patients with newly diagnosed non-severe lymphopenic gliomas following radiation and temozolomide Phase I/II Principal Investigator Chheda, Milan Disease Site Brain and Nervous System Learn more about this…

201901009

A Phase I/II Study of Nivolumab plus or minus Ipilimumab in Combination with Multi-fraction Stereotactic Radiosurgery for Recurrent High-grade Radiation-relapsed Meningioma Phase I/II Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System Learn more…

201903023

Pilot Study of Same-session MR-only Simulation and Treatment with Stereotactic MRI-guided Adaptive Radiotherapy (SMART) for Oligometastases of the Spine Phase N/A Principal Investigator Henke, Lauren Disease Site Anus; Bones and Joints; Brain and Nervous System;…

201905095

GBM AGILE Phase II/III (Cancer Control) Principal Investigator Ansstas, George Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201908018

Mapping Draining Lymph Nodes in CNS Malignancies Phase I Principal Investigator Johanns, Tanner Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov

201911203

Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease Phase III (Cancer Prevention) Principal Investigator Abraham, Christopher Disease Site Anus; Bones and Joints; Breast;…

202003050

Safety and efficacy study of retifanlimab and epacadostat in combination with radiation and bevacizumab in patients with recurrent gliomas Phase II Principal Investigator Chheda, Milan Disease Site Brain and Nervous System Learn more about this…

202003072

A Pilot Study to Assess the Safety, Feasibility, and Immunogenicity of a Neoantigen-based Personalized DNA Vaccine in Patients with Newly Diagnosed, Unmethylated Glioblastoma Phase I Principal Investigator Johanns, Tanner Disease Site Brain and Nervous System…

202006111

A feasibility study to correlate cognitive changes of IDH-mutant and IDH-wildtype glioma patients after chemoradiotherapy with radiation dose to the resting state networks Phase N/A Principal Investigator Huang, Jiayi Disease Site Brain and Nervous System…

202009128

A Phase 1, Open-Label, Multicenter, Dose Escalation and Expansion Study of PRT811 in Subjects with Advanced Solid Tumors, CNS Lymphoma, and Recurrent High-Grade Gliomas Phase I (Cancer Control) Principal Investigator Johanns, Tanner Disease Site Anus;…

202011112

Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients with Recurrent Select Rare CNS Cancers Phase II Principal Investigator Chheda, Milan Disease Site Brain and Nervous System Learn more about this study at:…

202012017

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1 Phase III (Cancer Control) Principal Investigator…

202012180

A PHASE II STUDY OF CHECKPOINT BLOCKADE IMMUNOTHERAPY IN PATIENTS WITH SOMATICALLY HYPERMUTATED RECURRENT GLIOBLASTOMA Phase II Principal Investigator Johanns, Tanner Disease Site Brain and Nervous System Learn more about this study at: clinicaltrials.gov