Joshua Rubin, MD, PhD

Joshua Rubin, MD, PhD

Pediatric Neuro-Oncologist

Primary Academic Title

Professor of Pediatrics, Division of Hematology and Oncology, WashU Medicine

Clinical Expertise

Pediatric brain tumors

Research Interest

Normal neuronal precursor cell proliferation, survival and migration in order to identify pathways that are likely to contribute to the genetics of pediatric brain tumors. We described a critical role for the chemokine receptor CSCR4 in normal cerebellar development and malignant brain tumor growth. This requirement creates a unique vulnerability in cancer growth to CXCR4 blockade, and we hope to exploit this in novel treatments for pediatric and adult patients with brain tumors.

Education

  • 1992: MSc, neuroscience, Albert Einstein College of Medicine, New York
  • 1994: MD/PhD, neuroscience, Albert Einstein College of Medicine

Training

  • 1994 - 1997: Resident, Children's Hospital and Harvard University, Boston
  • 1997 - 2000: Clinical fellow, hematology/oncology, Children's Hospital and Dana-Farber Cancer Institute, Boston

Board Certification

  • 2000: American Board of Pediatrics, Pediatric Hematology/Oncology

Selected Research Publications

Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host.
  • Gonzalez-Aponte MF, Damato AR, Simon T, [...] Rubin JB, Herzog ED
  • Cancer Cell 2025
Epigenetic developmental mechanisms underlying sex differences in cancer.
  • Rubin JB, Abou-Antoun T, Ippolito JE, [...] Yang L
  • J Clin Invest 2024

View All Publications

Contact Information

  • Siteman Kids at St. Louis Children’s Hospital

    1 Children's Place
    St. Louis, MO 63110

Phone Numbers

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