South St. Louis County

Siteman Cancer Center’s South St. Louis County facility is located at Interstate 55 and Butler Hill Road and has been in operation since January 2012. We bring world-class cancer care to patients in the greater St. Louis area, southern Mo. and Ill., and beyond. Our 37,000-square-foot complex is a fresh, light-filled space where patients can receive treatment and consult with their physicians. At about 16 acres, the building site incorporates green space for patients and families to enjoy, including land set aside for a future healing garden.

The Washington University medical oncologists, radiation oncologists and surgeons who staff the south county facility also work at Siteman’s main campus in St. Louis and collaborate regularly with other Siteman and Washington University physicians. These doctors practice multidisciplinary care, coordinating schedules with their colleagues so patients can see as many as three physicians in one trip and have their entire treatment plan determined in one visit.

Our south county staff includes registered nurses with specialized training in caring for cancer patients. A research coordinator is also available to talk with patients about possible participation in clinical trials, which provide access to new medications and treatments not available at most cancer centers.

Patients who come to our south county location can also take advantage of a wide range of support services and therapies aimed at helping them feel their best as they undergo treatment for cancer. Some of our programs include Therapeutic Horticulture with the Missouri Botanical Gardens, Touch Therapy with therapy dogs, and gentle yoga. We also have trained social workers on staff who can help patients with specific problems at home or at work that might arise during treatment.

PDF of driving directions and a campus map


Patients and visitors shouldn’t have any difficulty finding a parking space at the south county location. Our building is served by a large lot, and there is no charge to park.  There is also a covered area where drivers can drop patients and guests off at the door.


If you or a loved one requires the use of a wheelchair, they are available to borrow inside the main door.

Treatments and Services

At south county, we offer a wide range of treatments and services, including:

  • Washington University Physician care
  • Chemotherapy and Immunotherapy treatments
  • Blood Transfusions
  • Radiation therapy
  • On-site laboratory services
  • Retail pharmacy services
  • CT and PET scans, MRI and Mammography
  • Access to clinical trials
  • Support programs and materials

Location Amenities

For the added comfort of our patients and guests, we provide a number of amenities, including:

  • Free Wifi throughout the building
  • An information center for patients and family who wish to research diseases and treatments
  • A lounge where patients who are receiving treatment and their family members can relax, with coffee and vending available

Washington University Cancer Center Pharmacy – South County

Normal business hours:
Monday through Friday 8:00 a.m. to 4:30 p.m.

Pharmacy location:
5225 Midamerica Plaza
St. Louis, MO 63129

Contact information:
Phone:   314-286-1785
Fax:  314-286-1788
Contact:  Tony Druger, Pharm.D.

Support Services

The Siteman Cancer Center offers a variety of support programs for patients and families at all of our locations. These programs range from support groups and exercise programs to educational sessions and pet therapy. Due to Covid-19 safety restrictions, many of these services have not been able to take place in-person. To continue supporting our patients on their journey, we have reshaped many of our services into a virtual format.

The following support programs are offered by Siteman- South County. All programs are held at the cancer center, 5225 Midamerica Plaza St. Louis, MO 63129. For more information, call 314-286-1950.

Therapeutic Horticulture with the Missouri Botanical Gardens

A therapeutic horticulturist will bring plants to make arrangements with patients, press note cards, make tea bags with different herbs, or discuss the medicinal benefits of plants and flowers.

When: TBD

Where: Siteman- South County, 5225 Midamerica Plaza, St. Louis, MO 63129

TOUCH Therapy with the Duo therapy dogs

Trained pet therapy dogs from Duo provide comfort to patients and their loved ones.

To learn more, call (314) 393-5782.

When: TBD

Where: Siteman- South County, 5225 Midamerica Plaza, St. Louis, MO 63129

Nutritional Support

A consultation with a registered dietitian to discuss nutritional needs of patients based on their disease and treatment type.

To learn more, call 314-286-2500.

Where: Siteman- South County, 5225 Midamerica Plaza, St. Louis, MO 63129

Social Workers

Social workers are available to help patients and families cope with the challenges and problems caused by cancer. They provide assistance with such issues as lodging and transportation, rehabilitation and hospice care, and advance directives. They also identify community resources related to housing, employment, legal issues and financial concerns. For more information or to reach a social worker at this facility, call 314-286-1106

Nutritional Support

A dietician on site is happy to work with you on nutrition and related items while you go through treatment. Your team can make a referral for you or you can call 314-286-0461 to make an appointment.

Also, be sure to ask your nurse if you qualify for free Ensure.

Scalp Cooling

Siteman can now help patients keep their hair during chemotherapy with scalp cooling, an innovative technology that protects the hair follicles. This technique has allowed thousands of patients from all over the world to feel more comfortable and confident as they undergo treatment for cancer.

We are pleased to offer scalp cooling at our South County location. Please click here for more information.

If you are interested in scalp cooling, please talk to your nurse coordinator.

Siteman Psychology Service

Patients and family members who come to our facility can make an appointment with a psychologist, free of charge, to discuss the emotional challenges posed by cancer and develop methods for coping.

For more information, visit our Siteman Psychology Service page.