Marco Colonna, MD

Marco Colonna, MD

Primary Academic Title

Professor of Pathology and Immunology, Section of Immunology and Molecular Pathology, Washington University School of Medicine

Research Interest

We study the cell surface receptors that activate or inhibit the function of natural killer cells and myeloid cells.

Selected Research Publications

Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells.
  • Saini A, Hopkins LS, Serna VA, [...] Colonna M, Oltz EM
  • Nat Commun 2026
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth.
  • Mateus-Tique J, Lakshmi A, Singh B, [...] Colonna M, [...] Brown BD
  • Cancer Cell 2026
Divergent ILC3 responses to PDGF-D control mucosal immunity.
  • Fachi JL, de Oliveira S, Trsan T, [...] Colonna M
  • Sci Immunol 2026
Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy.
  • Giovannoni F, Strathdee CA, Faust Akl C, [...] Colonna M, [...] Quintana FJ
  • Nat Cancer 2025
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression.
  • Rea A, Santana-Hernández S, Villanueva J, [...] Colonna M, [...] Muntasell A
  • Nat Immunol 2025
Intestinal epithelium-derived IL-34 reprograms macrophages to mitigate gastrointestinal tract graft-versus-host disease.
  • Rayasam A, Moe A, Kudek M, [...] Colonna M, [...] Drobyski WR
  • Sci Transl Med 2025
Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy.
  • Sultan H, Takeuchi Y, Ward JP, [...] Colonna M, [...] Schreiber RD
  • Nature 2024
Diversity of group 1 innate lymphoid cells in human tissues.
  • Jaeger N, Antonova AU, Kreisel D, [...] Colonna M
  • Nat Immunol 2024
High-dimensional single-cell analysis of human natural killer cell heterogeneity.
  • Rebuffet L, Melsen JE, Escalière B, [...] Colonna M, [...] Vivier E
  • Nat Immunol 2024
Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis.
  • Gaertner F, Ishikawa-Ankerhold H, Stutte S, [...] Colonna M, [...] Massberg S
  • Nature 2024