Reyka Jayasinghe, PhD

Reyka Jayasinghe, PhD

Primary Academic Title

Assistant Professor, Department of Internal medicine, Washington University School of Medicine

Research Interest

The long-term goal of my research is to use single-cell and spatial technologies to understand the gene expression dynamics in tumor and immune cells during cancer initiation, treatment, and disease progression, with a particular focus on prostate and pancreatic cancer and blood cancers including multiple myeloma. Further, our lab is actively sequencing patients affected by various cancer types in underrepresented groups to better characterize the genomic and transcriptional cancer landscape of understudied ethnic groups. In the long run, we hope to both address cancer disparities and strengthen our understandings about the interplay between cancer and pre-cancerous lesions and the tumor microenvironment during disease progression.

Education

  • 2013: BS, San Francisco State University, CA
  • 2018: PhD, Washington University School of Medicine, St. Louis, MO

Training

  • 2018 - 2020: Postdoctoral Research Associate, Washington University School of Medicine, St. Louis, MO

Selected Research Publications

Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma.
  • Ohlstrom DJ, Pilcher WC, Michaud ME, [...] Jayasinghe RG, [...] Bhasin MK
  • Blood Cancer Discov 2026
Combined Flt3L and CD40 agonism restores dendritic cell-driven T cell immunity in pancreatic cancer.
  • Hogg GD, Weinstein AG, Kingston NL, [...] Jayasinghe RG, [...] DeNardo DG
  • Sci Immunol 2025
Single-cell transcriptomic profiling reveals diversity in human iNKT cells across hematologic tissues.
  • Jayasinghe RG, Hollingsworth D, Schedler NC, [...] Mavers M
  • Cell Rep 2025
Tumour evolution and microenvironment interactions in 2D and 3D space.
  • Mo CK, Liu J, Chen S, [...] Jayasinghe RG, [...] Ding L
  • Nature 2024
Multi-scale signaling and tumor evolution in high-grade gliomas.
  • Liu J, Cao S, Imbach KJ, [...] Jayasinghe RG, [...] Ding L
  • Cancer Cell 2024
Epigenetic regulation during cancer transitions across 11 tumour types.
  • Terekhanova NV, Karpova A, Liang WW, [...] Jayasinghe RG, [...] Ding L
  • Nature 2023

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