Gabriel Mbalaviele, PhD

Primary Academic Title

Professor of Medicine, Division of Bone and Mineral Diseases, WashU Medicine

Research Interest

Role of inflammasomes and gasdermins in pathophysiology.

Education

1992: PhD, University of Paris 7

Training

2007 - 2010: Associate research fellow, St. Louis, Mo.

Selected Research Publications

Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation.

Zou W, Wang C, Li Y, [...] Mbalaviele G
J Bone Miner Res 2025

Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation.

Zou W, Wang C, Li Y, [...] Mbalaviele G
bioRxiv 2025

NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx.

Kaur K, Alippe Y, Wang C, [...] Mbalaviele G
bioRxiv 2025

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss.

Wang C, Kaur K, Xu C, Abu-Amer Y, Mbalaviele G
Elife 2024

Tmem178 Negatively Regulates IL-1β Production Through Inhibition of the NLRP3 Inflammasome.

Khanna K, Yan H, Mehra M, [...] Mbalaviele G, [...] Faccio R
Arthritis Rheumatol 2024

View All Publications