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A Phase 1b Study of JNJ-78278343, Targeting Human Kallikrein 2 (KLK2) in Combination With Other Agents for Metastatic Prostate Cancer

  • Protocol Number: 202310120
  • Principal Investigator: Pachynski, Russell
  • Cancer Types: GU: Bladder, Kidney, Prostate, Testicular

Learn more about this study at: clinicaltrials.gov

For more information on this trial, contact us here:

Phone
800-600-3606
Email
[email protected]

Brief Summary

The purpose of this study is to identify the recommended phase 2 regimen(s) RP2R(s) of pasritamig and combination regimens in Part 1 (dose escalation) and to determine safety at the putative RP2R(s) of pasritamig with the combination regimens in Part 2 (dose expansion).

Protocol Interventions

Drug: Pasritamig, Drug: Cetrelimab, Drug: Cabazitaxel, Drug: Docetaxel, Drug: Apalutamide, Drug: Enzalutamide, Drug: Darolutamide, Drug: Abiraterone acetate plus prednisone (AAP), Drug: Lutetium Lu-177 vipivotide tetraxetan, Drug: JNJ-101556143