Maxim Artyomov, PhD

Primary Academic Title

Professor of Pathology and Immunology, Division of Immunobiology, WashU Medicine

Research Interest

Systems immunology using cross-disciplinary approaches to data generation and analysis; novel fundamental biology in immunometabolism, cancer immunology and aging; single-cell RNA-sequencing, transcriptional data analysis, chip-sequencing, metabolomics, data integration, peptide-MHC binding

Education

2009: PhD, Massachusetts Institute of Technology

Training

2009 - 2012: Postdoctoral fellow, Broad Institute of MIT & Harvard, Cambridge, Mass.

Selected Research Publications

Non-negative matrix factorization and deconvolution as a dual simplex problem.

Kleverov D, Aladyeva E, Serdyukov A, Artyomov MN
Genome Biol 2026

Accurate chromatin marks peak calling with Omnipeak.

Shpynov O, Artyomov MN
Nucleic Acids Res 2026

Human immune aging.

Terekhova M, Bohacova P, Artyomov MN
Immunity 2025

Inflammaging in aged tissues drives remodeling of the CD8 + T cell compartment.

Shchukina I, Rodriguez-Hernandez CJ, Ruiz HS, [...] Artyomov MN
bioRxiv 2025

CORESH: a gene signature-based search engine for public gene expression datasets.

Sukhov V, Nugmanova A, Vorontsov Y, [...] Artyomov M, Sergushichev A
Nucleic Acids Res 2025

Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan.

Chen S, Liu R, Mo CK, [...] Artyomov MN, [...] Chen F
Nat Genet 2025

Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling.

Bohacova P, Terekhova M, Tsurinov P, [...] Artyomov MN
Immunity 2024

ZBTB46 coordinates angiogenesis and immunity to control tumor outcome.

Kabir AU, Zeng C, Subramanian M, [...] Artyomov MN, Choi K
Nat Immunol 2024

Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy.

Sultan H, Takeuchi Y, Ward JP, [...] Artyomov MN, Schreiber RD
Nature 2024

Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans.

Chauvin SD, Ando S, Holley JA, [...] Artyomov MN, [...] Miner JJ
Nat Commun 2024

Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release.

Tufan T, Comertpay G, Villani A, [...] Artyomov MN, [...] Ravichandran KS
Nature 2024

Public platform with 39,472 exome control samples enables association studies without genotype sharing.

Artomov M, Loboda AA, Artyomov MN, Daly MJ
Nat Genet 2024

Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB-CD8+ memory T cells and accumulation of type 2 memory T cells.

Terekhova M, Swain A, Bohacova P, [...] Artyomov MN
Immunity 2023

T cell control of inflammaging.

Shchukina I, Bohacova P, Artyomov MN
Semin Immunol 2023

Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity.

Ryu S, Spadaro O, Sidorov S, [...] Artyomov MN, [...] Dixit VD
J Clin Invest 2023

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