Grant A. Challen, PhD

Grant A. Challen, PhD

Primary Academic Title

Professor of Medicine, Division of Oncology, Section of Molecular Oncology, Washington University School of Medicine

Research Interest

Determining the effect of DNA methylation mediated by the de novo DNA methyltransferase enzymes on hematopoietic stem cell functio

Education

  • 2006: PhD, developmental biology, University of Queensland, Brisbane, Australia

Training

  • 2006 - 2012: Postdoctoral fellow, hematopoietic stem cells, Baylor College of Medicine, Houston

Selected Research Publications

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis.
  • Young KA, Hosseini M, Mistry JJ, [...] Challen GA, [...] Trowbridge JJ
  • Nat Commun 2025
RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia.
  • Kong T, Laranjeira ABA, Letson CT, [...] Challen GA, Oh ST
  • Nat Commun 2025
Spatial Mapping of Hematopoietic Clones in Human Bone Marrow.
  • Young AL, Davis HC, Cox MJ, [...] Challen GA
  • Blood Cancer Discov 2024
Droplet Digital PCR for Oncogenic KMT2A Fusion Detection.
  • Young AL, Davis HC, Challen GA
  • J Mol Diagn 2023
KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.
  • Issa N, Bjeije H, Wilson ER, [...] Challen GA
  • Leukemia 2023
DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression.
  • Kong T, Laranjeira ABA, Yang K, [...] Challen GA, [...] Oh ST
  • Nat Cancer 2023
Effect of Clonal Hematopoiesis on Cardiovascular Disease in People Living with HIV.
  • Wiley B, Parsons TM, Burkart S, [...] Challen GA
  • Exp Hematol 2022

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