Grant A. Challen, PhD

Grant A. Challen, PhD

Primary Academic Title

Professor of Medicine, Division of Oncology, Section of Molecular Oncology, Washington University School of Medicine

Research Interest

Determining the effect of DNA methylation mediated by the de novo DNA methyltransferase enzymes on hematopoietic stem cell functio


  • 2006: PhD, developmental biology, University of Queensland, Brisbane, Australia


  • 2006 - 2012: Postdoctoral fellow, hematopoietic stem cells, Baylor College of Medicine, Houston

Selected Research Publications

Spatial Mapping of Hematopoietic Clones in Human Bone Marrow.
  • Young AL, Davis HC, Cox MJ, [...] Challen GA
  • Blood Cancer Discov 2024
Droplet Digital PCR for Oncogenic KMT2A Fusion Detection.
  • Young AL, Davis HC, Challen GA
  • J Mol Diagn 2023
KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.
  • Issa N, Bjeije H, Wilson ER, [...] Challen GA
  • Leukemia 2023
DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression.
  • Kong T, Laranjeira ABA, Yang K, [...] Challen GA, [...] Oh ST
  • Nat Cancer 2023
Effect of Clonal Hematopoiesis on Cardiovascular Disease in People Living with HIV.
  • Wiley B, Parsons TM, Burkart S, [...] Challen GA
  • Exp Hematol 2022
Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21.
  • Zhang CR, Ostrander EL, Kukhar O, [...] Challen GA
  • Blood Cancer Discov 2022
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
  • Maifrede S, Le BV, Nieborowska-Skorska M, [...] Challen GA, Skorski T
  • Cancer Res 2021
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling.
  • Hormaechea-Agulla D, Matatall KA, Le DT, [...] Challen GA, [...] King KY
  • Cell Stem Cell 2021
LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.
  • Marinaccio C, Suraneni P, Celik H, [...] Challen GA, [...] Crispino JD
  • Cancer Discov 2021

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