Ju-Fang Chang, PhD

Ju-Fang Chang, PhD

Primary Academic Title

Assistant Professor, Department of Internal Medicine, Washington University School of Medicine

Research Interest

T cell engineering is a type of immunotherapy that involves delivering synthetic proteins to T cells to manipulate their function in combating cancer. Given that protein function is intricately linked to its molecular structure, careful design of these synthetic proteins is crucial for the effectiveness of engineered T cells to achieve desired clinical outcomes. I worked on developing a type of synthetic receptors that combine the advantages of flexible antigen targeting with full TCR complex functionality. My long-term goal is to understand how immune proteins function in structural details and apply this knowledge to develop novel strategies for cell therapies against cancer.

Education

  • 1996: BSc, National Tsing-Hua University, Taiwan
  • 1999: PhD, University of Cambridge, UK

Selected Research Publications

Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors.
  • Chang JF, Landmann JH, Chang TC, [...] Singh N
  • Cancer Discov 2024
Regulatory Considerations for Genome-Edited T-cell Therapies.
  • Jadlowsky JK, Chang JF, Spencer DH, [...] Singh N
  • Cancer Immunol Res 2024

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