David Yuan-Sou Chen, MD, PhD

David Yuan-Sou Chen, MD, PhD


Primary Academic Title

Assistant Professor of Medicine Division of Dermatology, Washington University School of Medicine

Clinical Expertise

Melanoma and other skin cancers

Research Interest

Genetic and epigenetic alterations acquired in the development of cancer.


  • 2012: MD, Washington University, St. Louis
  • 2012: PhD, molecular cell biology, Washington University


  • 2012 - 2013: Intern, Barnes-Jewish Hospital, St. Louis
  • 2013 - 2016: Resident, dermatology, Barnes-Jewish Hospital
  • 2013 - 2016: Fellow, Oliver Langenberg Physician Scientist Training Program, Washington University

Board Certification

  • 2016: American Board of Dermatology

Selected Research Publications

CD4 T cells and toxicity from immune checkpoint blockade.
  • Earland N, Zhang W, Usmani A, [...] Chen DY, [...] Newman AM
  • Immunol Rev 2023
Melanoma in a patient with DNMT3A overgrowth syndrome.
  • Chen DY, Sutton LA, Ramakrishnan SM, [...] Ley TJ
  • Cold Spring Harb Mol Case Stud 2023
Combined Kdm6a and Trp53 Deficiency Drives the Development of Squamous Cell Skin Cancer in Mice.
  • Shea LK, Akhave NS, Sutton LA, [...] Chen DY
  • J Invest Dermatol 2023
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma.
  • Lozano AX, Chaudhuri AA, Nene A, [...] Chen DY, [...] Newman AM
  • Nat Med 2022
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
  • Smith AM, LaValle TA, Shinawi M, [...] Chen DY, [...] Ley TJ
  • Nat Commun 2021

View All Publications

Contact Information

  • Washington University Medical Campus

    4921 Parkview Place
    Saint Louis, MO 63110

Phone Numbers

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