David  DeNardo, PhD

David DeNardo, PhD

Primary Academic Title

Professor of Medicine, Division of Oncology, Section of Molecular Oncology, Washington University School of Medicine

Research Interest

Identifying the molecular mechanisms by which malignant cells derail anti-tumor immune responses to instead favor immune programs that facilitate tumor progression to metastasis. Understanding the immune microenvironment in which tumor cells reside will allow for the identification of pharmacological targets that can be exploited to destroy malignant disease.


  • 2005: PhD, molecular cell biology, Baylor College of Medicine, Houston


  • 2006 - 2010: Postdoctoral fellow, cancer immunology, University of California, San Francisco

Selected Research Publications

Senescent CAFs mediate immunosuppression and drive breast cancer progression.
  • Ye J, Baer JM, Faget DV, [...] DeNardo DG, Stewart SA
  • Cancer Discov 2024
Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression.
  • Ye J, Baer JM, Faget DV, [...] DeNardo DG, Stewart SA
  • Cancer Discov 2024
Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer.
  • Bulle A, Liu P, Seehra K, [...] DeNardo DG, [...] Lim KH
  • Nat Commun 2024
"RIPping" off Pancreas Cancer's Blockage of Immune Surveillance.
  • Liu X, Sells BE, DeNardo DG
  • Cancer Discov 2024
Epigenetic regulation during cancer transitions across 11 tumour types.
  • Terekhanova NV, Karpova A, Liang WW, [...] DeNardo DG, [...] Ding L
  • Nature 2023
Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction.
  • Selli ME, Landmann JH, Terekhova M, [...] DeNardo D, [...] Singh N
  • Blood 2023

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