Brian  Dieckgraefe, MD, PhD

Brian Dieckgraefe, MD, PhD

Primary Academic Title

Associate Professor of Medicine, Division of Gastroenterology, Washington University School of Medicine

Research Interest

Ulcerative colitis (UC) is associated with a substantially increased risk of colonic adenocarcinoma, perhaps arising from mitogen overexpression. We have applied the Affymetrix GeneChip to profile gene expression in UC patients. Members of the regeneration gene family are among the most highly expressed mRNAs in UC. Our analysis of SAGE databases also revealed overexpression in several malignancies, including prostate, breast, and colon adenocarcinoma. Our research is focused on characterizing the functional role for this poorly understood mitogen family.


  • 1988: MD/PhD, molecular and cell biology, Washington University, St. Louis


  • 1988 - 1991: Resident, internal medicine, Washington University, St. Louis
  • 1991 - 1993: Clinical fellow, gastroenterology, Washington University
  • 1993 - 1996: Postdoctoral research fellow, medicine, Washington University

Selected Research Publications

Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells.
  • Bishnupuri KS, Sainathan SK, Ciorba MA, Houchen CW, Dieckgraefe BK
  • Mol Cancer Res 2022