Roberta Faccio, PhD

Roberta Faccio, PhD

Primary Academic Title

Professor of Orthopaedic Surgery, Washington University School of Medicine

Research Interest

Understanding the cellular mechanisms that lead to bone metastases. Specifically, the interactions between cancer cells, immune cells and the bone micronvironment. Using genetic and pharmachological approaches to dissect the signaling pathways leading to immune suppression and osteoclast activation in breast cancer-induced bone metastases.

Education

  • 2000: PhD, cell science and biotechnologies, University of Bari Aldo Moro, Bari, Italy

Training

  • 2000 - 2004: Research associate, pathology and immunology, Barnes-Jewish Hospital, St. Louis

Selected Research Publications

Tmem178 Negatively Regulates IL-1β Production Through Inhibition of the NLRP3 Inflammasome.
  • Khanna K, Yan H, Mehra M, [...] Faccio R
  • Arthritis Rheumatol 2024
The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone.
  • Pal S, Perrien DS, Yumoto T, Faccio R, [...] Pacifici R
  • J Clin Invest 2022

View All Publications