Todd Fehniger, MD, PhD

Bone Marrow Transplant Specialist, Medical Oncologist

Primary Academic Title

Professor of Medicine, Division of Oncology, Sections of Stem Cell Biology and Bone Marrow Transplantation, Washington University School of Medicine

Clinical Expertise

Lymphoma, cellular therapy and bone marrow transplantation

Research Interest

The long-term goals of my laboratory are to better understand the molecular programs that regulate natural killer (NK) cell development and activation and translate basic NK cell biology into novel treatments for patients with cancer. My clinical interests are lymphoma, cellular therapy and hematopoietic stem-cell transplantation.

Education

2000: PhD, immunology, Ohio State University, Columbus
2002: MD, Ohio State University

Training

2002 - 2004: Intern and resident, internal medicine, Washington University, St. Louis
2004 - 2008: Fellow, hematology and oncology, Washington University

Board Certification

2006: American Board of Internal Medicine, Internal Medicine
2009: American Board of Internal Medicine, Medical Oncology

Selected Research Publications

Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303.

Russler-Germain DA, Krysiak K, Ramirez C, [...] Fehniger TA
Blood Adv 2023

T-BET and EOMES sustain mature human NK cell identity and antitumor function.

Wong P, Foltz JA, Chang L, [...] Fehniger TA
J Clin Invest 2023

Computational prediction of MHC anchor locations guides neoantigen identification and prioritization.

Xia H, McMichael J, Becker-Hapak M, [...] Fehniger TA, [...] Griffith M
Sci Immunol 2023

Allogeneic natural killer cell therapy.

Berrien-Elliott MM, Jacobs MT, Fehniger TA
Blood 2023

Phase 1/dose expansion trial of brentuximab vedotin and lenalidomide in relapsed or refractory diffuse large B-cell lymphoma.

Ward J, Berrien-Elliott MM, Gomez F, [...] Fehniger TA, Bartlett NL
Blood 2022

Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant.

Bednarski JJ, Zimmerman C, Berrien-Elliott MM, [...] Fehniger TA
Blood 2022

A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells.

Cubitt CC, McClain E, Becker-Hapak M, [...] Fehniger TA
Mol Ther Oncolytics 2022

Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy.

Berrien-Elliott MM, Becker-Hapak M, Cashen AF, [...] Fehniger TA
Blood 2022

Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia.

Berrien-Elliott MM, Foltz JA, Russler-Germain DA, [...] Fehniger TA
Sci Transl Med 2022

Memory-like Differentiation Enhances NK Cell Responses to Melanoma.

Marin ND, Krasnick BA, Becker-Hapak M, [...] Fehniger TA
Clin Cancer Res 2021

A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy.

Becker-Hapak MK, Shrestha N, McClain E, [...] Fehniger TA
Cancer Immunol Res 2021

Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies.

Kerbauy LN, Marin ND, Kaplan M, [...] Fehniger TA, Rezvani K
Clin Cancer Res 2021

Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with Indolent Non-Hodgkin Lymphoma.

Foltz JA, Hess BT, Bachanova V, [...] Fehniger TA
Clin Cancer Res 2021

Flow cytometry-based ex vivo murine NK cell cytotoxicity assay.

Wong P, Wagner JA, Berrien-Elliott MM, Schappe T, Fehniger TA
STAR Protoc 2021

Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia.

Berrien-Elliott MM, Cashen AF, Cubitt CC, [...] Fehniger TA
Cancer Discov 2020

Contact Information

Washington University Medical Campus

4921 Parkview Place
Saint Louis, MO 63110

Phone Numbers

Appointments: (314) 747-7222
Toll Free: (800) 600-3606

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