Todd Fehniger, MD, PhD

Todd Fehniger, MD, PhD

Bone Marrow Transplant Specialist, Medical Oncologist

Primary Academic Title

Professor of Medicine, Division of Oncology, Sections of Stem Cell Biology and Bone Marrow Transplantation, WashU Medicine

Clinical Expertise

Lymphoma, cellular therapy and bone marrow transplantation

Research Interest

The long-term goals of my laboratory are to better understand the molecular programs that regulate natural killer (NK) cell development and activation and translate basic NK cell biology into novel treatments for patients with cancer. My clinical interests are lymphoma, cellular therapy and hematopoietic stem-cell transplantation.

Education

  • 2000: PhD, immunology, Ohio State University, Columbus
  • 2002: MD, Ohio State University

Training

  • 2002 - 2004: Intern and resident, internal medicine, Washington University, St. Louis
  • 2004 - 2008: Fellow, hematology and oncology, Washington University

Board Certification

  • 2006: American Board of Internal Medicine, Internal Medicine
  • 2009: American Board of Internal Medicine, Medical Oncology

Selected Research Publications

First-in-Human Phase I Study of a CD16A Bispecific Innate Cell Engager, AFM24, Targeting EGFR-Expressing Solid Tumors.
  • El-Khoueiry A, Saavedra O, Thomas J, [...] Fehniger TA, [...] Lopez J
  • Clin Cancer Res 2025
Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer.
  • Lee S, Ricci B, Tran J, [...] Fehniger TA, Faccio R
  • Nat Commun 2025
MicroRNA-146a deficiency enhances host protection against murine cytomegalovirus.
  • Wong P, Leong JW, Sohn H, [...] Fehniger TA
  • Eur J Immunol 2024
Neoantigen landscape supports feasibility of personalized cancer vaccine for follicular lymphoma.
  • Ramirez CA, Becker-Hapak M, Singhal K, [...] Fehniger TA
  • Blood Adv 2024
Fat matters for natural killer cell activity.
  • Wong P, Fehniger TA
  • Nat Immunol 2024
Memory-like differentiation enhances NK cell responses against colorectal cancer.
  • Marin ND, Becker-Hapak M, Song WM, [...] Fehniger TA
  • Oncoimmunology 2024
T-BET and EOMES sustain mature human NK cell identity and antitumor function.
  • Wong P, Foltz JA, Chang L, [...] Fehniger TA
  • J Clin Invest 2023
Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction.
  • Selli ME, Landmann JH, Terekhova M, [...] Fehniger TA, [...] Singh N
  • Blood 2023

Contact Information

  • Gary C. Werths Building at Siteman Cancer Center

    4500 Forest Park Avenue
    Saint Louis, MO 63108

Phone Numbers

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