Benjamin Garcia, PhD

Benjamin Garcia, PhD

Primary Academic Title

Professor and Head of the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine

Research Interest

Developing methodologies for the analysis of protein post-translational modifications (PTMs) and modified proteomes, with a particular interest in understanding the roles of protein PTMs during cancer pathogenesis, neurodegeneration and cell differentiation

Education

  • 2005: PhD, chemistry, University of Virginia, Charlottesville

Training

  • 2005 - 2008: Postdoctoral fellow, genomic biology, University of Illinois, Urbana-Champaign

Selected Research Publications

Circular Engineered Sortase for Interrogating Histone H3 in Chromatin.
  • Whedon SD, Lee K, Wang ZA, [...] Garcia BA, Cole PA
  • J Am Chem Soc 2024
A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma.
  • Hamilton AK, Radaoui AB, Tsang M, [...] Garcia BA, [...] Diskin SJ
  • Cancer Cell 2024
Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.
  • Shipman GA, Padilla R, Horth C, [...] Garcia BA, [...] Majewski J
  • Genome Biol 2024
Mass Spectrometry Analysis of Nucleic Acid Modifications: From Beginning to Future.
  • Xie Y, Brás-Costa C, Lin Z, Garcia BA
  • Mass Spectrom Rev 2024
The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA.
  • Xie Y, Chai P, Till NA, [...] Garcia BA, Flynn RA
  • Cell 2024
Histone H3.3 lysine 9 and 27 control repressive chromatin at cryptic enhancers and bivalent promoters.
  • Trovato M, Bunina D, Yildiz U, [...] Garcia BA, [...] Noh KM
  • Nat Commun 2024
An integrated structural model of the DNA damage-responsive H3K4me3 binding WDR76:SPIN1 complex with the nucleosome.
  • Liu X, Zhang Y, Wen Z, [...] Garcia BA, [...] Washburn MP
  • Proc Natl Acad Sci USA 2024
SMYD5 methylation of rpL40 links ribosomal output to gastric cancer.
  • Park J, Wu J, Szkop KJ, [...] Garcia BA, [...] Mazur PK
  • Nature 2024
Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation.
  • Nacev BA, Dabas Y, Paul MR, [...] Garcia BA, [...] Allis CD
  • Nat Commun 2024
An Unbiased Proteomic Platform for Activity-based Arginylation Profiling.
  • Lin Z, Xie Y, Gongora J, [...] Garcia BA
  • bioRxiv 2024

View All Publications