Benjamin Garcia, PhD

Benjamin Garcia, PhD

Primary Academic Title

Professor and Head of the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine

Research Interest

Developing methodologies for the analysis of protein post-translational modifications (PTMs) and modified proteomes, with a particular interest in understanding the roles of protein PTMs during cancer pathogenesis, neurodegeneration and cell differentiation


  • 2005: PhD, chemistry, University of Virginia, Charlottesville


  • 2005 - 2008: Postdoctoral fellow, genomic biology, University of Illinois, Urbana-Champaign

Selected Research Publications

Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation.
  • Nacev BA, Dabas Y, Paul MR, [...] Garcia BA, [...] Allis CD
  • Nat Commun 2024
An Unbiased Proteomic Platform for Activity-based Arginylation Profiling.
  • Lin Z, Xie Y, Gongora J, [...] Garcia BA
  • bioRxiv 2024
FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia.
  • Sung PJ, Selvam M, Riedel SS, [...] Garcia BA, [...] Carroll M
  • Leukemia 2024
Bifunctional Peptide Nanofibrils for Targeted Protein Degradation.
  • Lin Z, Garcia BA, Lv D
  • Angew Chem Int Ed Engl 2024
SWAMNA: a comprehensive platform for analysis of nucleic acid modifications.
  • Xie Y, De Luna Vitorino FN, Chen Y, [...] Garcia BA
  • Chem Commun (Camb) 2023
Acetyl-methyllysine marks chromatin at active transcription start sites.
  • Lu-Culligan WJ, Connor LJ, Xie Y, [...] Garcia BA, [...] Simon MD
  • Nature 2023
Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment.
  • Rogers LC, Kremer JC, Brashears CB, [...] Garcia BA, [...] Van Tine BA
  • Clin Cancer Res 2023
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas.
  • Jessa S, Mohammadnia A, Harutyunyan AS, [...] Garcia BA, [...] Kleinman CL
  • Nat Genet 2022
Nucleome programming is required for the foundation of totipotency in mammalian germline development.
  • Nagano M, Hu B, Yokobayashi S, [...] Garcia BA, [...] Saitou M
  • EMBO J 2022

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