Benjamin Garcia, PhD

Benjamin Garcia, PhD

Primary Academic Title

Professor and Head of the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine

Research Interest

Developing methodologies for the analysis of protein post-translational modifications (PTMs) and modified proteomes, with a particular interest in understanding the roles of protein PTMs during cancer pathogenesis, neurodegeneration and cell differentiation

Education

  • 2005: PhD, chemistry, University of Virginia, Charlottesville

Training

  • 2005 - 2008: Postdoctoral fellow, genomic biology, University of Illinois, Urbana-Champaign

Selected Research Publications

Circular Engineered Sortase for Interrogating Histone H3 in Chromatin.
  • Whedon SD, Lee K, Wang ZA, [...] Garcia BA, Cole PA
  • J Am Chem Soc 2024
A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma.
  • Hamilton AK, Radaoui AB, Tsang M, [...] Garcia BA, [...] Diskin SJ
  • Cancer Cell 2024
Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.
  • Shipman GA, Padilla R, Horth C, [...] Garcia BA, [...] Majewski J
  • Genome Biol 2024
Mass Spectrometry Analysis of Nucleic Acid Modifications: From Beginning to Future.
  • Xie Y, Brás-Costa C, Lin Z, Garcia BA
  • Mass Spectrom Rev 2024
Histone H3.3 lysine 9 and 27 control repressive chromatin at cryptic enhancers and bivalent promoters.
  • Trovato M, Bunina D, Yildiz U, [...] Garcia BA, [...] Noh KM
  • Nat Commun 2024
An integrated structural model of the DNA damage-responsive H3K4me3 binding WDR76:SPIN1 complex with the nucleosome.
  • Liu X, Zhang Y, Wen Z, [...] Garcia BA, [...] Washburn MP
  • Proc Natl Acad Sci USA 2024
SMYD5 methylation of rpL40 links ribosomal output to gastric cancer.
  • Park J, Wu J, Szkop KJ, [...] Garcia BA, [...] Mazur PK
  • Nature 2024
Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation.
  • Nacev BA, Dabas Y, Paul MR, [...] Garcia BA, [...] Allis CD
  • Nat Commun 2024
An Unbiased Proteomic Platform for Activity-based Arginylation Profiling.
  • Lin Z, Xie Y, Gongora J, [...] Garcia BA
  • bioRxiv 2024
FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia.
  • Sung PJ, Selvam M, Riedel SS, [...] Garcia BA, [...] Carroll M
  • Leukemia 2024
Bifunctional Peptide Nanofibrils for Targeted Protein Degradation.
  • Lin Z, Garcia BA, Lv D
  • Angew Chem Int Ed Engl 2024
SWAMNA: a comprehensive platform for analysis of nucleic acid modifications.
  • Xie Y, De Luna Vitorino FN, Chen Y, [...] Garcia BA
  • Chem Commun (Camb) 2023

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