Benjamin Garcia, PhD

Benjamin Garcia, PhD

Primary Academic Title

Professor and Head of the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine

Research Interest

Developing methodologies for the analysis of protein post-translational modifications (PTMs) and modified proteomes, with a particular interest in understanding the roles of protein PTMs during cancer pathogenesis, neurodegeneration and cell differentiation


  • 2005: PhD, chemistry, University of Virginia, Charlottesville


  • 2005 - 2008: Postdoctoral fellow, genomic biology, University of Illinois, Urbana-Champaign

Selected Research Publications

Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment.
  • Rogers LC, Kremer JC, Brashears CB, [...] Garcia BA, [...] Van Tine BA
  • Clin Cancer Res 2023
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas.
  • Jessa S, Mohammadnia A, Harutyunyan AS, [...] Garcia BA, [...] Kleinman CL
  • Nat Genet 2022
Nucleome programming is required for the foundation of totipotency in mammalian germline development.
  • Nagano M, Hu B, Yokobayashi S, [...] Garcia BA, [...] Saitou M
  • EMBO J 2022
Data-Independent Acquisition for the Detection of Mononucleoside RNA Modifications by Mass Spectrometry.
  • Janssen KA, Xie Y, Kramer MC, Gregory BD, Garcia BA
  • J Am Soc Mass Spectrom 2022
Reprogramming of the epigenome in neurodevelopmental disorders.
  • Wilson KD, Porter EG, Garcia BA
  • Crit Rev Biochem Mol Biol 2022

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