Benjamin Garcia, PhD

Benjamin Garcia, PhD

Primary Academic Title

Professor and Head of the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine

Research Interest

Developing methodologies for the analysis of protein post-translational modifications (PTMs) and modified proteomes, with a particular interest in understanding the roles of protein PTMs during cancer pathogenesis, neurodegeneration and cell differentiation

Education

  • 2005: PhD, chemistry, University of Virginia, Charlottesville

Training

  • 2005 - 2008: Postdoctoral fellow, genomic biology, University of Illinois, Urbana-Champaign

Selected Research Publications

NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.
  • Jeong J, Hausmann S, Dong H, [...] Garcia BA, [...] Gozani O
  • Nature 2026
An unbiased proteomic platform for ATE1-based arginylation profiling.
  • Lin Z, Xie Y, Gongora J, [...] Garcia BA
  • Nat Chem Biol 2025
The mitotic STAG3-cohesin complex shapes male germline nucleome.
  • Nagano M, Hu B, Ogata K, [...] Garcia BA, [...] Saitou M
  • Nat Struct Mol Biol 2025
KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia.
  • Michmerhuizen NL, Heikamp EB, Iacobucci I, [...] Garcia BA, [...] Mullighan CG
  • Cancer Discov 2025
A needed nomenclature for nucleosomes.
  • Keogh MC, Almouzni G, Andrews AJ, [...] Garcia BA, [...] Young NL
  • Mol Cell 2025
Development and application of GlycanDIA workflow for glycomic analysis.
  • Xie Y, Liu X, Yi L, [...] Garcia BA
  • Nat Commun 2025
Native nucleosomes intrinsically encode genome organization principles.
  • Park S, Merino-Urteaga R, Karwacki-Neisius V, [...] Garcia BA, [...] Ha T
  • Nature 2025
An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling.
  • Lin Z, Xie Y, Gongora J, [...] Garcia BA
  • bioRxiv 2025
H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability.
  • Yuan W, Huang YC, LeBlanc C, [...] Garcia BA, [...] Jacob Y
  • Nat Commun 2025
Circular Engineered Sortase for Interrogating Histone H3 in Chromatin.
  • Whedon SD, Lee K, Wang ZA, [...] Garcia BA, Cole PA
  • J Am Chem Soc 2024

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