Gautam Dantas, PhD

Gautam Dantas, PhD

Primary Academic Title

Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine

Research Interest

Our lab focuses on (1) understanding and predicting how diverse microbiomes respond to chemical and biological perturbations, and (2) harnessing these insights to rationally design therapeutic strategies to curtail antibiotic resistant pathogens and remedy pathological microbiome and host states. Relevant to the Siteman Cancer Center, we are currently exploring novel applications for synthetic bacterial and fungal probiotics to allow for targeted drug delivery and therapeutic immune modulation targeting numerous cancer types.


  • 2005: PhD, biochemistry, University of Washington, Seattle


  • 2006 - 2009: Fellow, genetics, Harvard University Medical School, Boston

Selected Research Publications

Genetically stable CRISPR-based kill switches for engineered microbes.
  • Rottinghaus AG, Ferreiro A, Fishbein SRS, Dantas G , Moon TS
  • Nat Commun 2022
Spontaneous Bacterial Peritonitis Caused by Bordetella hinzii.
  • Wang GC, Wallace MJ, Krishnan G, [...] Dantas G, Fleckenstein JM
  • Emerging Infect Dis 2021

View All Publications