S. Peter Goedegebuure, PhD

S. Peter Goedegebuure, PhD

Primary Academic Title

Associate Professor of Surgery, Section of General Surgery, Division of Endocrine and Oncologic Surgery, Washington University School of Medicine

Research Interest

Design of immune-based treatment for cancer, in particular breast and pancreas cancer. We currently focus on the design of tumor vaccines that induce T lymphocyte-mediated anti-tumor responses. At the same time, we try to better understand mechanisms of immune suppression in cancer patients with the goal to inhibit/overcome immune suppression. Our ultimate goal is to test a combination of vaccination and neutralization of immune suppression in cancer patients.

Selected Research Publications

pVACview: an interactive visualization tool for efficient neoantigen prioritization and selection.
  • Xia H, Hoang MH, Schmidt E, [...] Goedegebuure SP, [...] Griffith M
  • Genome Med 2024
Tumour evolution and microenvironment interactions in 2D and 3D space.
  • Mo CK, Liu J, Chen S, [...] Goedegebuure SP, [...] Ding L
  • Nature 2024
Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment.
  • Chiorazzi M, Martinek J, Krasnick B, [...] Goedegebuure SP, [...] Flavell RA
  • J Immunother Cancer 2023
Computational prediction of MHC anchor locations guides neoantigen identification and prioritization.
  • Xia H, McMichael J, Becker-Hapak M, [...] Goedegebuure SP, [...] Griffith M
  • Sci Immunol 2023

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