Young Ah Goo, PhD

Young Ah Goo, PhD

Primary Academic Title

Professor, Department of Biochemistry and Molecular Biophysics (BMB), Department of Genetics, WashU Medicine

Research Interest

My research focuses on the application of mass spectrometry-based 'omics' technologies to address fundamental biological questions, with particular emphasis on the discovery of diagnostic and prognostic biomarkers and therapeutic targets for human diseases such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), breast, prostate, and liver cancers, and leukemia. Additional interests include studying human pathogens and investigating the biological roles and regulatory mechanisms of post-translational modifications - including phosphorylation, glycosylation, methylation, acetylation, sumoylation, and ubiquitination - as well as chemical cross-linking applications in structural biology.

Education

  • 2002: PhD , University of Washington, Seattle, WA

Training

  • 2002 - 2004: Postdoctoral, Proteomics/Prostate Cancer , Institute for Systems Biology, Seattle, WA

Selected Research Publications

Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity.
  • Liu T, Zhang M, Farsh T, [...] Goo YA, [...] DeSelm CJ
  • Nat Commun 2025
Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library.
  • Singh AK, Lewis CD, Boas CAWV, [...] Goo YA, [...] Hallahan DE
  • Clin Cancer Res 2024