Jeffrey Gordon, MD

Jeffrey Gordon, MD

Primary Academic Title

Dr. Robert J. Glaser Distinguished University Professor of Developmental Biology, Washington University School of Medicine

Research Interest

We have three projects related to cancer: a gnotobiotic transgenic mouse model to study the molecular features of gastric stem cells and the effect of attachment of Helicobacter pylori to these epithelial progenitors on gastric tumorigenesis; a transgenic mouse model of metastatic prostate cancer to examine initiation and progression of neuroendocrine cancers in general and CaP in particular; and biochemical, biophysical and genetic approaches and yeast as a model organism to study the regulation of protein N-myristoylation and its biological significance.


  • 1973: MD, University of Chicago


  • 1973 - 1975: Intern and resident, internal medicine, Washington University, St. Louis
  • 1975 - 1978: Research associate, molecular biology, National Cancer Institute, Bethesda, Md.
  • 1978 - 1979: Resident, internal medicine, Washington University
  • 1979 - 1981: Fellow, gastroenterology, Washington University

Selected Research Publications

TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy.
  • Di Luccia B, Molgora M, Khantakova D, [...] Gordon JI, Colonna M
  • Sci Immunol 2024