David Gutmann, MD, PhD

David Gutmann, MD, PhD


Primary Academic Title

Director, Neurofibromatosis Center; Donald O. Schnuck Family Chair and Professor of Neurology, Washington University School of Medicine

Clinical Expertise

Inherited cancer syndromes

Research Interest

The molecular biology of nervous system tumors, including neurofibromatosis 1, neurofibromatosis 2 and tuberous sclerosis 2 tumor suppressor gene products.


  • 1980: MS, human genetics, University of Michigan, Ann Arbor
  • 1984: PhD, microbiology and immunology, University of Michigan, Ann Arbor
  • 1986: MD, University of Michigan


  • 1986 - 1990: Resident, neurology, University of Pennsylvania, Philadelphia
  • 1990 - 1993: Postdoctoral fellow, human molecular genetics, Howard Hughes Medical Institute and University of Michigan, Ann Arbor

Board Certification

  • 1992: American Board of Psychiatry and Neurology, Neurology

Selected Research Publications

Nf1 mutation disrupts activity-dependent oligodendroglial plasticity and motor learning in mice.
  • Pan Y, Hysinger JD, Yalçın B, [...] Gutmann DH, Monje M
  • Nat Neurosci 2024
Next Directions in the Neuroscience of Cancers Arising outside the CNS.
  • Amit M, Anastasaki C, Dantzer R, [...] Gutmann DH, Borniger JC
  • Cancer Discov 2024
Estrogen-induced glial IL-1β mediates extrinsic retinal ganglion cell vulnerability in murine Nf1 optic glioma.
  • Tang Y, Chatterjee J, Wagoner N, Bozeman S, Gutmann DH
  • Ann Clin Transl Neurol 2024
Brain injury drives optic glioma formation through neuron-glia signaling.
  • Chatterjee J, Koleske JP, Chao A, [...] Gutmann DH
  • Acta Neuropathol Commun 2024
Stem cell modeling of nervous system tumors.
  • Furnari FB, Anastasaki C, Bian S, [...] Gutmann DH
  • Dis Model Mech 2024
Pediatric low-grade glioma: State-of-the-art and ongoing challenges.
  • Fangusaro J, Jones DT, Packer RJ, Gutmann DH, [...] Bandopadhayay P
  • Neuro-oncology 2024
A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.
  • Chen Z, Giotti B, Kaluzova M, [...] Gutmann DH, [...] Hambardzumyan D
  • J Clin Invest 2023
Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation.
  • Milde T, Fangusaro J, Fisher MJ, [...] Gutmann DH
  • Neuro-oncology 2023
Clinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1.
  • Romo CG, Piotrowski AF, Campian JL, [...] Gutmann DH, [...] Blakeley JO
  • Neuro-oncology 2023
Cancer neuroscience: State of the field, emerging directions.
  • Winkler F, Venkatesh HS, Amit M, [...] Gutmann DH, [...] Monje M
  • Cell 2023
Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma.
  • Chen Z, Soni N, Pinero G, [...] Gutmann DH, [...] Hambardzumyan D
  • Nat Commun 2023

View All Publications

Contact Information

  • Washington University Medical Campus

    4921 Parkview Place
    Saint Louis, MO 63110

Phone Numbers

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