Richard Harbison, MD, MS

Richard Harbison, MD, MS

Head and Neck

Clinical Expertise

Otolaryngology – Head and Neck Cancer

Research Interest

My research is centered on understanding the complex interactions between cancer and the immune system, with a particular focus on how metabolism influences these interactions. A key aspect of my research involves investigating how diet-induced metabolic alterations affect the tumor microenvironment and subsequently modulate anti-tumor immune cell function. In parallel, we are working to identify how malignant cells manipulate the local metabolic milieu to evade the anti-tumor immune response. Our goal is to identify metabolic vulnerabilities within the tumor microenvironment that can be targeted to enhance anti-tumor immunity paving the way for innovative treatments that harness the full potential of the immune system to combat cancer.

Education

  • 2009: BS, University of Denver, Denver CO
  • 2013: MD, University of Colorado - Anschutz Medical Campus, Aurora, CO
  • 2017: MS, University of Washington Seattle, WA

Training

  • 2013 - 2014: Intern, General Surgery , University of Washington, Seattle, WA
  • 2015 - 2017: T32 Postdoctoral Research Fellowship, University of Washington , Seattle, WA
  • 2014 - 2020: Resident, Otolaryngology - Head & Neck Surgery , University of Washington, Seattle, WA
  • 2020 - 2021: Postdoctoral Research Fellowship, Immunometabolism, Johns Hopkins University School of Medicine, Baltimore, MD
  • 2021 - 2022: Fellowship, Head and Neck Surgical Oncology , Johns Hopkins University School of Medicine, Baltimore, MD

Board Certification

  • 2022: American Board of Otolaryngology - Head and Neck Surgery

Selected Research Publications

Immunotherapeutic strategies in head and neck cancer: challenges and opportunities.
  • Liu X, Harbison RA, Varvares MA, Puram SV , Peng G
  • J Clin Invest 2025
Tumor extracellular vesicle-derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming.
  • Ma F, Liu X, Zhang Y, [...] Harbison RA, [...] Peng G
  • Sci Transl Med 2025

Contact Information

  • Washington University Medical Campus

    Gary C. Werths Building at Siteman Cancer Center
    4500 Forest Park Avenue
    Saint Louis, MO 63108

    Center for Advanced Medicine at Siteman Cancer Center
    4921 Parkview Place
    Saint Louis, MO 63110

    Parkview Tower
    1 Parkview Place
    Saint Louis, MO 63110

    S. Lee Kling Proton Therapy Center
    224 Euclid Ave.
    Saint Louis, MO 63110

    Siteman Kids at St. Louis Children’s Hospital
    1 Children's Place
    St. Louis, MO 63110

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