Angela Hirbe, MD, PhD

Angela Hirbe, MD, PhD

Medical Oncologist

Primary Academic Title

Assistant Professor of Medicine, Division of Oncology, Section of Medical Oncology, Washington University School of Medicine

Clinical Expertise

As a member of our sarcoma specialist team, Dr. Hirbe cares for patients diagnosed with sarcomas and rare tumors through treatment and recovery. Learn more about how Dr. Hirbe and Siteman approach extremity and non-extremity sarcoma treatment and recovery.

Research Interest

Utilize genomic information from human sarcoma to better understand the development and progression of these cancers in order to identify biomarkers and therapeutic targets. The pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), an aggressive soft tissue sarcoma that occurs at an increased frequency in patients with the Neurofibromatosis Type 1 (NF1) tumor predisposition syndrome.


  • 2009: MD, PhD in biology, Washington University in St. Louis


  • 2009 - 2011: Resident, internal medicine, Washington University
  • 2011 - 2012: Chief resident, internal medicine, Washington University
  • 2012 - 2016: Hematology and oncology fellow, postdoctoral research fellow, Washington University

Board Certification

  • 2012: American Board of Internal Medicine

Selected Research Publications

A Single Arm Phase 2 Trial of Trametinib in Patients With Locally Advanced or Metastatic Epithelioid Hemangioendothelioma.
  • Schuetze SM, Ballman KV, Heise R, [...] Hirbe A, [...] Rubin BP
  • Clin Cancer Res 2024
Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology.
  • Larsson AT, Bhatia H, Calizo A, [...] Hirbe AC
  • Neuro-oncology 2023
CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression.
  • Kohlmeyer JL, Lingo JJ, Kaemmer CA, [...] Hirbe AC, [...] Quelle DE
  • Clin Cancer Res 2023
Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma.
  • Dehner CA, Bell RC, Cao Y, [...] Hirbe AC
  • JCO Precis Oncol 2023
Mutations involving TGFB and MAPK may be associated with malignancy in granular cell tumors.
  • Dehner CA, Moon T, Lyu Y, [...] Hirbe AC
  • Genes Chromosomes Cancer 2023
A Systematic Review of Recent and Ongoing Clinical Trials in Patients With the Neurofibromatoses.
  • Acar S, Nieblas-Bedolla E, Armstrong AE, Hirbe AC
  • Pediatr Neurol 2022
Plexiform neurofibroma: shedding light on the investigational agents in clinical trials.
  • Acar S, Armstrong AE, Hirbe AC
  • Expert Opin Investig Drugs 2022
An open-label single-arm phase II study of regorafenib for the treatment of angiosarcoma.
  • Agulnik M, Schulte B, Robinson S, Hirbe AC, [...] Van Tine BA
  • Eur J Cancer 2021
TYK2 in Cancer Metastases: Genomic and Proteomic Discovery.
  • Borcherding DC, He K, Amin NV, Hirbe AC
  • Cancers (Basel) 2021

Contact Information

  • South St. Louis County

    5225 Midamerica Plaza
    St. Louis, MO 63129

  • Washington University Medical Campus

    4921 Parkview Place
    Saint Louis, MO 63110

Phone Numbers

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