Alex Holehouse, PhD

Alex Holehouse, PhD

Primary Academic Title

Assistant Professor, Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine

Research Interest

My lab works on understanding the molecular basis for how intrinsically disordered regions (IDRs) carry out cellular functions, and how this goes wrong in disease. Given almost every cancer-associated protein contains larger IDRs, this is a rich area for us in terms of relating molecular biophysics to human disease. Our goal is to enable the mechanistic interpretation of mutations in IDRs in the context of cancer - i.e. how and why do mutations cause disordered regions to misfunction.

Education

  • 2017: PhD, Computational Biophysics , Washington University, St. Louis, MO

Training

  • 2017 - 2019: Postdoctoral Fellow Department of Biomedical Engineering , Washington University, St. Louis, MO

Selected Research Publications

Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors.
  • Chang JF, Landmann JH, Chang TC, [...] Holehouse AS, Singh N
  • Cancer Discov 2024
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation.
  • Chadda R, Kaushik V, Ahmad IM, [...] Holehouse AS, [...] Antony E
  • Nucleic Acids Res 2024
Direct prediction of intermolecular interactions driven by disordered regions.
  • Ginell GM, Emenecker RJ, Lotthammer JM, Usher ET, Holehouse AS
  • bioRxiv 2024
Phase transition of GvpU regulates gas vesicle clustering in bacteria.
  • Li Z, Shen Q, Usher ET, [...] Holehouse AS, [...] Lu GJ
  • Nat Microbiol 2024
Dissecting the biophysics and biology of intrinsically disordered proteins.
  • Banerjee PR, Holehouse AS, Kriwacki R, [...] Mendell JT
  • Trends Biochem Sci 2024
Intrinsically disordered regions are poised to act as sensors of cellular chemistry.
  • Moses D, Ginell GM, Holehouse AS, Sukenik S
  • Trends Biochem Sci 2023

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