Michael Holtzman, MD

Michael Holtzman, MD

Primary Academic Title

Selma and Herman Seldin Professor of Medicine and Director, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine

Research Interest

We are defining the molecular basis for genetic susceptibility to epithelial metaplasia. Our current model focuses on induction of chronic airway epithelial hyperplasia and metaplasia inducible by viral infection as well as structure-function of the E1A oncoprotein. Key words: Apoptosis, epithelial cell hyperplasia, respiratory virus, mucosal immunity, EGF receptor, interferon signal transduction, airway diseases.


  • 1975: MD, Northwestern University, Chicago


  • 1975 - 1977: Resident, internal medicine, Duke University, Durham, N.C.
  • 1977 - 1980: Fellow, pulmonary and critical care medicine, University of California, San Francisco

Selected Research Publications

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.
  • Parichha A, Suresh V, Chatterjee M, [...] Holtzman MJ, [...] Tole S
  • Nat Commun 2022
Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia.
  • Chatterjee J, Sanapala S, Cobb O, [...] Holtzman MJ, Gutmann DH
  • Nat Commun 2021
Selective Imaging of Lung Macrophages Using [11C]PBR28-Based Positron Emission Tomography.
  • Chen DL, Agapov E, Wu K, [...] Holtzman MJ
  • Mol Imaging Biol 2021

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