Joseph Ippolito, MD, PhD

Joseph Ippolito, MD, PhD


Primary Academic Title

Associate Professor of Radiology, Mallinckrodt Institute of Radiology, Associate Professor of Biochemistry and Molecular Biophysics, Director, Center for Clinical Imaging Research (CCIR), Washington University School of Medicine

Clinical Expertise

Radiology, abdominal imaging, magnetic resonance imaging

Research Interest

Precision medicine through metabolism-based imaging and therapy: from laboratory to clinical translation. My major research focus is two-part. First, we are developing new clinical molecular imaging research technologies with MRI and mass spectrometry to predict poor outcomes in patients with prostate cancer at the time of diagnosis. Second, we are discovering the molecular basis for the effects of biological sex on cancer metabolism, identifying new methods on how imaging and therapy can be applied differently to males and females with cancer to improve outcomes for all.


  • 2007: PhD, molecular biophysics, Washington University, St. Louis
  • 2007: MD, Washington University


  • 2008 - 2012: Resident, diagnostic radiology, Mallinckrodt Institute of Radiology, St. Louis
  • 2012 - 2013: Fellow, body magnetic resonance imaging, Mallinckrodt Institute of Radiology

Board Certification

  • 2012: American Board of Radiology, diagnostic radiology

Selected Research Publications

NCCN Guidelines® Insights: Prostate Cancer, Version 3.2024.
  • Schaeffer EM, Srinivas S, Adra N, [...] Ippolito JE, [...] Freedman-Cass DA
  • J Natl Compr Canc Netw 2024
Beyond Average: α-Particle Distribution and Dose Heterogeneity in Bone Metastatic Prostate Cancer.
  • Benabdallah N, Lu P, Abou DS, [...] Ippolito JE, [...] Thorek DLJ
  • J Nucl Med 2024
Prostate Cancer, Version 4.2023, NCCN Clinical Practice Guidelines in Oncology.
  • Schaeffer EM, Srinivas S, Adra N, [...] Ippolito JE, [...] Freedman-Cass DA
  • J Natl Compr Canc Netw 2023
Imaging modalities for measuring body composition in patients with cancer: opportunities and challenges.
  • Shah UA, Ballinger TJ, Bhandari R, [...] Ippolito JE
  • J Natl Cancer Inst Monographs 2023
NCCN Guidelines® Insights: Prostate Cancer, Version 1.2023.
  • Schaeffer EM, Srinivas S, Adra N, [...] Ippolito JE, [...] Freedman-Cass DA
  • J Natl Compr Canc Netw 2022
Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment.
  • Sponagel J, Jones JK, Frankfater C, [...] Ippolito JE
  • Med (N Y) 2022

View All Publications

Contact Information

  • Washington University Medical Campus

    4921 Parkview Place
    Saint Louis, MO 63110

  • West St. Louis County

    Medical Office Building 2, 10 Barnes West Drive
    Creve Coeur, MO 63141

Phone Numbers

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