Tom Lin, PhD

Tom Lin, PhD

Primary Academic Title

Instructor, Department of Biochemistry & Molecular Biophysics

Research Interest

My primary research interest is to investigate the regulatory roles of post-translational modifications, especially protein arginylation installed by arginyltransferase ATE1, in the human proteome and health. Arginylation is closely associated with cancer progression. Dysregulation of ATE1/arginylation is indicated in cancers from many aspects such as cancer malignancy, resistance, and metastasis. My research program aims to reveal protein substrates of arginylation in cancer cells/tissues and elucidate their precise modification sites using various proteomics approaches. Following up the target discovery, cancer-associated proteins will be further investigated for their potential to be targeted for therapeutic strategies.

Education

  • 2009: BS, Zhengzhou University
  • 2012: MS, Peking University
  • 2017: PhD, University of Tennessee Health Sciences Center

Training

  • 2017 - 2021: Posdoc, Department of Chemistry, University of Pennsylvania

Selected Research Publications

An Unbiased Proteomic Platform for Activity-based Arginylation Profiling.
  • Lin Z, Xie Y, Gongora J, [...] Garcia BA
  • bioRxiv 2024
Bifunctional Peptide Nanofibrils for Targeted Protein Degradation.
  • Lin Z, Garcia BA, Lv D
  • Angew Chem Int Ed Engl 2024
Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment.
  • Rogers LC, Kremer JC, Brashears CB, Lin Z, [...] Van Tine BA
  • Clin Cancer Res 2023

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