Yongjian Liu, PhD

Yongjian Liu, PhD

Primary Academic Title

Associate Professor of Radiology, Division of Oncology, Washington University School of Medicine

Research Interest

My research has focused on the development and validation of novel molecular probes from preclinical research to translational PET imaging and therapy. These imaging agents are built upon a number of platforms including peptides, small molecules, antibodies, and nanostructures and are radiolabeled with various radionuclides according to the biological half-life of the biomolecules and decay half-life of the radionuclides. Through the collaboration with other investigators, I have translated four imaging agents for human imaging including 2 radiolabeled antibodies for cancer patients PET imaging, a targeted nanoparticle for human atherosclerosis and a CCR2 targeted ECLi1 peptide for human inflammation imaging.

Education

  • 2000: MS, environmental science, Zhejiang University, Hangzhou, Zhejiang, China
  • 2007: PhD, radiochemistry, University of Missouri, Columbia

Training

  • 2007 - 2011: Postdoctoral fellow, Washington University, St. Louis

Selected Research Publications

Visualizing Immune Checkpoint Inhibitors Derived Inflammation in Atherosclerosis.
  • Lou L, Detering L, Luehmann H, [...] Liu Y
  • Circ Res 2024
Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library.
  • Singh AK, Lewis CD, Boas CAWV, [...] Liu Y, [...] Hallahan DE
  • Clin Cancer Res 2024
Chemokine Receptor 2 Targeted PET/CT Imaging Distant Metastases in Pancreatic Ductal Adenocarcinoma.
  • Zhang X, Detering L, Heo GS, [...] Liu Y
  • ACS Pharmacol Transl Sci 2024
Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
  • Ma P, Liu J, Qin J, [...] Liu Y, [...] Lavine KJ
  • Circulation 2024
A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes.
  • Wang Y, Wang D, Lin J, [...] Liu Y, [...] Zhang K
  • Angew Chem Int Ed Engl 2022

View All Publications