Ulrike Lorenz, PhD

Ulrike Lorenz, PhD

Primary Academic Title

Professor, Pathology and Immunology, Washington University School of Medicine

Clinical Expertise

Pathology and Immunology

Research Interest

The long-term goal of our research is to study how different components of the immune system are regulated in physiological and pathophysiological settings, and how they can be manipulated to modulate cancer therapies. In particular, we are interested in the role of regulatory signaling molecules in T cells. My laboratory has a long-standing interest in the tyrosine phosphatase SHP-1 and its role as a critical negative regulator using biochemical, functional, and genetic approaches. Combining our long-term interest in T cell signaling and a novel protein degron system we recently developed, we are currently working on the generation of regulatable safer CAR T cells. We believe our findings will have clinical implications for tumor immunity.

Education

  • 1989: PhD, Freie Universität/ Max-Planck-Institut, Berlin, Germany

Training

  • 1989 - 1991: Postdoctoral Fellow, Max-Planck-Institut for Molecular Genetics, Berlin, Germany
  • 1991 - 1996: Postdoctoral Fellow, Beth Israel Hospital/Harvard Medical School, Boston, MA

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