Zhi Hong Lu, PhD

Zhi Hong Lu, PhD

Radiology

Primary Academic Title

Assistant Professor, Department of Radiation Oncology, WashU Medicine

Clinical Expertise

Cancer Biology and Tumor Immunology

Research Interest

My work for the past several years has focused on engineering adenoviral vectors for novel functional capacities. One aspect is the safe and efficient nucleic acid delivery to targeted cell populations in vivo, which remains a significant unmet need in the fields of cancer cell and gene therapy. We have developed strategies for enhanced gene transfer into primary B and T cells and dendritic cells in stringent in vivo contexts and can be combined with additional well characterized adenovirus modifications towards applications in immune cells engineering, gene therapy, vaccines, oncolytics in the context of cancer immunotherapy.

Education

  • 1990: BS, Fudan University, Shanghai, China
  • 1999: PhD, University of Mississippi Medical Center, Jackson, MS

Training

  • 1999 - 2002: Postdoctoral, Molecular Oncology , Washington University School of Medicine, St. Louis, MO
  • 2002 - 2006: Research Fellow, Division of Oncology , Washington University School of medicine, St. Louis, MO

Selected Research Publications

In-vivo-targeted gene delivery using adenovirus-antibody site-specific covalent conjugates.
  • Rice-Boucher PJ, Kashentseva EA, Dmitriev IP, [...] Lu ZH
  • Mol Ther Methods Clin Dev 2025
In vivo targeted gene delivery using Adenovirus-antibody molecular glue conjugates.
  • Rice-Boucher PJ, Kashentseva EA, Dmitriev IP, [...] Lu ZH
  • bioRxiv 2025
Adenoviral vectors infect B lymphocytes in vivo.
  • Rice-Boucher PJ, Mendonça SA, Alvarez AB, [...] Lu ZH, [...] Curiel DT
  • Mol Ther 2023

View All Publications