Cynthia Ma, MD, PhD

Medical Oncologist

Primary Academic Title

Professor of Medicine, Division of Oncology, Section of Breast Oncology, Washington University School of Medicine

Clinical Expertise

Breast cancer

Research Interest

Breast cancer, endocrine therapy, developmental therapeutics, biomarkers and pharmacogenetics.

Education

1990: MD, Beijing Medical University
1997: PhD, developmental biology, University of Cincinnati

Training

1990 - 1991: Resident, internal medicine and endocrinology, Beijing Medical University
1997 - 1998: Postdoctoral fellow, endocrinology and oncology, University of Cincinnati
1998 - 2001: Intern and resident, internal medicine, New Hanover Regional Medical Center, Wilmington, N.C.
2001 - 2005: Fellow, hematology and oncology, Mayo Clinic, Rochester, Minn.

Board Certification

2001: American Board of Internal Medicine, Internal Medicine
2004: American Board of Internal Medicine, Hematology
2005: American Board of Internal Medicine, Medical Oncology

Selected Research Publications

Genomic Complexity Predicts Resistance to Endocrine Therapy and CDK4/6 Inhibition in Hormone Receptor-Positive (HR+)/HER2-Negative Metastatic Breast Cancer.

Davis AA, Luo J, Zheng T, [...] Ma CX
Clin Cancer Res 2023

A phase II study of palbociclib plus letrozole plus trastuzumab as neoadjuvant treatment for clinical stages II and III ER+ HER2+ breast cancer (PALTAN).

Ademuyiwa FO, Northfelt DW, O'Connor T, [...] Ma CX
NPJ Breast Cancer 2023

Circulating tumour DNA characterisation of invasive lobular carcinoma in patients with metastatic breast cancer.

Davis AA, Gerratana L, Clifton K, [...] Ma CX, [...] Cristofanilli M
EBioMedicine 2022

Evaluation of Sensitivity to Endocrine Therapy Index (SET2,3) for Response to Neoadjuvant Endocrine Therapy and Longer-Term Breast Cancer Patient Outcomes (Alliance Z1031).

Suman VJ, Du L, Hoskin T, [...] Ma C, [...] Symmans WF
Clin Cancer Res 2022

KSTAR: An algorithm to predict patient-specific kinase activities from phosphoproteomic data.

Crowl S, Jordan BT, Ahmed H, Ma CX , Naegle KM
Nat Commun 2022

CALGB 40603 (Alliance): Long-Term Outcomes and Genomic Correlates of Response and Survival After Neoadjuvant Chemotherapy With or Without Carboplatin and Bevacizumab in Triple-Negative Breast Cancer.

Shepherd JH, Ballman K, Polley MC, [...] Ma C, [...] Sikov WM
J Clin Oncol 2022

The Phase II MutHER Study of Neratinib Alone and in Combination with Fulvestrant in HER2-Mutated, Non-amplified Metastatic Breast Cancer.

Ma CX, Luo J, Freedman RA, [...] Bose R
Clin Cancer Res 2022

A phase II trial of an alternative schedule of palbociclib and embedded serum TK1 analysis.

Krishnamurthy J, Luo J, Suresh R, [...] Ma CX
NPJ Breast Cancer 2022

Effective Treatment of Established Bone Metastases Can Be Achieved by Combinatorial Osteoclast Blockade and Depletion of Granulocytic Subsets.

Capietto AH, Lee S, Clever D, [...] Ma CX, Faccio R
Cancer Immunol Res 2021

Intermittent fasting in the prevention and treatment of cancer.

Clifton KK, Ma CX, Fontana L, Peterson LL
CA Cancer J Clin 2021

Breast Cancer, HER2 Mutations, and Overcoming Drug Resistance.

Bose R, Ma CX
N Engl J Med 2021

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment.

Sun H, Cao S, Mashl RJ, [...] Ma CX, [...] Raphael BJ
Nat Commun 2021

Phase I/II Trial of Exemestane, Ribociclib, and Everolimus in Women with HR+/HER2- Advanced Breast Cancer after Progression on CDK4/6 Inhibitors (TRINITI-1).

Bardia A, Hurvitz SA, DeMichele A, [...] Ma C, [...] Moulder S
Clin Cancer Res 2021

Evaluation of Racial/Ethnic Differences in Treatment and Mortality Among Women With Triple-Negative Breast Cancer.

Cho B, Han Y, Lian M, [...] Ma C, Liu Y
JAMA Oncol 2021

Serial single-cell genomics reveals convergent subclonal evolution of resistance as early-stage breast cancer patients progress on endocrine plus CDK4/6 therapy.

Griffiths JI, Chen J, Cosgrove PA, [...] Ma C, [...] Bild AH
Nat Cancer 2021

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Contact Information

Washington University Medical Campus

4921 Parkview Place
Saint Louis, MO 63110

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