Nima Mosammaparast, MD, PhD

Nima Mosammaparast, MD, PhD

Primary Academic Title

Associate Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine

Research Interest

Understanding DNA repair in the chromatin context, and how DNA repair is regulated. Specifically, studying human chromatin modifying enzymes, particularly histone and DNA demethylases that are involved in DNA repair, and their differential regulation in tumor cells.

Education

  • 2005: PhD, University of Virginia, Charlottesville, Va.
  • 2006: MD, University of Virginia

Training

  • 2006 - 2009: Resident, clinical pathology, Brigham and Women's Hospital, Boston, Mass.
  • 2009 - 2011: Fellow, pathology, Brigham and Women's Hospital

Selected Research Publications

YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks.
  • Tsao N, Lombardi PM, Park A, [...] Mosammaparast N
  • Mol Cell 2025
TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks.
  • Kong L, Cheng C, Cheruiyot A, [...] Mosammaparast N, [...] You Z
  • Nat Commun 2024
The debranching enzyme Dbr1 regulates lariat turnover and intron splicing.
  • Buerer L, Clark NE, Welch A, [...] Mosammaparast N, Fairbrother WG
  • Nat Commun 2024
YTHDC1 cooperates with the THO complex to prevent RNA damage-induced DNA breaks.
  • Tsao N, Olabode J, Rodell R, [...] Mosammaparast N
  • bioRxiv 2024
How RNA impacts DNA repair.
  • Tsao N, Ashour ME, Mosammaparast N
  • DNA Repair (Amst) 2023
RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer.
  • Compadre AJ, van Biljon LN, Valentine MC, [...] Mosammaparast N, [...] Mullen MM
  • Clin Cancer Res 2023
Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex.
  • Jia J, Hilal T, Bohnsack KE, [...] Mosammaparast N, [...] Wahl MC
  • Nat Commun 2023
Rapid profiling of DNA replication dynamics using mass spectrometry-based analysis of nascent DNA.
  • Ashour ME, Byrum AK, Meroni A, [...] Mosammaparast N
  • J Cell Biol 2023
SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.
  • Lukinović V, Hausmann S, Roth GS, [...] Mosammaparast N, Reynoird N
  • Cancer Discov 2022