Nima Mosammaparast, MD, PhD

Nima Mosammaparast, MD, PhD

Primary Academic Title

Associate Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine

Research Interest

Understanding DNA repair in the chromatin context, and how DNA repair is regulated. Specifically, studying human chromatin modifying enzymes, particularly histone and DNA demethylases that are involved in DNA repair, and their differential regulation in tumor cells.


  • 2005: PhD, University of Virginia, Charlottesville, Va.
  • 2006: MD, University of Virginia


  • 2006 - 2009: Resident, clinical pathology, Brigham and Women's Hospital, Boston, Mass.
  • 2009 - 2011: Fellow, pathology, Brigham and Women's Hospital

Selected Research Publications

How RNA impacts DNA repair.
  • Tsao N, Ashour ME, Mosammaparast N
  • DNA Repair (Amst) 2023
RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer.
  • Compadre AJ, van Biljon LN, Valentine MC, [...] Mosammaparast N, [...] Mullen MM
  • Clin Cancer Res 2023
Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex.
  • Jia J, Hilal T, Bohnsack KE, [...] Mosammaparast N, [...] Wahl MC
  • Nat Commun 2023
Rapid profiling of DNA replication dynamics using mass spectrometry-based analysis of nascent DNA.
  • Ashour ME, Byrum AK, Meroni A, [...] Mosammaparast N
  • J Cell Biol 2023
SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.
  • Lukinović V, Hausmann S, Roth GS, [...] Mosammaparast N, Reynoird N
  • Cancer Discov 2022
Immunoaffinity Purification of Epitope-Tagged DNA Repair Complexes from Human Cells.
  • Townley BA, Soll JM, Mosammaparast N
  • Methods Mol Biol 2022
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.
  • Mahlokozera T, Patel B, Chen H, [...] Mosammaparast N, [...] Kim AH
  • Nat Commun 2021
Aberrant RNA methylation triggers recruitment of an alkylation repair complex.
  • Tsao N, Brickner JR, Rodell R, [...] Mosammaparast N
  • Mol Cell 2021
Mechanisms of damage tolerance and repair during DNA replication.
  • Ashour ME, Mosammaparast N
  • Nucleic Acids Res 2021
The complexity and regulation of repair of alkylation damage to nucleic acids.
  • Tsao N, Schärer OD, Mosammaparast N
  • Crit Rev Biochem Mol Biol 2021