Amit Pathak, PhD

Primary Academic Title

Associate Professor, Department of Mechanical Engineering and Materials Science, Washington University

Research Interest

Tumor cells navigate the 3D tissue environment surrounding the primary tumor through physical cell-ECM interactions. However, the biophysical basis for this mechano-regulated tumor cell migration is not completely understood. This gap in knowledge remains due to a lack of in-vitro matrix scaffolds that permit controlled manipulation of various ECM parameters in cell culture scaffolds composed of soft ECMs that mimic tissue microenvironment.

Education

2008: PhD, biomechanics, University of California, Santa Barbara

Training

2009 - 2012: Fellow, bioengineering, University of California, Berkeley

Selected Research Publications

Epithelial multicellular clustering enabled by polarized macrophages on soft matrices.

Zmuda H, Pathak A
FASEB J 2023

Matrix obstructions cause multiscale disruption in collective epithelial migration by suppressing leader cell function.

Lee YL, Mathur J, Walter C, Zmuda H, Pathak A
Mol Biol Cell 2023

Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality.

Almeida JA, Mathur J, Lee YL, Sarker B, Pathak A
Mol Biol Cell 2023

Reciprocal intra- and extra-cellular polarity enables deep mechanosensing through layered matrices.

Walter C, Mathur J, Pathak A
Cell Rep 2023

Nuclear export inhibition jumbles epithelial-mesenchymal states and gives rise to migratory disorder in healthy epithelia.

Krull CM, Li H, Pathak A
Elife 2023

A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration.

Hwang PY, Mathur J, Cao Y, [...] Pathak A, Longmore GD
Dev Cell 2023

Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues.

Flick Jaecker F, Almeida JA, Krull CM, Pathak A
Mol Biol Cell 2022

View All Publications

Siteman Cancer Center ranked No. 10 among U.S. cancer centers

Diversity, Equity & Inclusion at Siteman

How Siteman is leading the way in personalized brain tumor treatment

Siteman Cancer Center expands proton therapy treatment

Siteman explains what every woman should know about endometrial cancer risk, symptoms and screening

Immunity boosting treatment enhances CAR-T cell therapy for blood cancers

$5.3 million grant supports research into lung cancer recurrence

Couple honors physician with gift for distinguished professorship

Siteman Cancer Center ranked No. 10 among U.S. cancer centers

Siteman Cancer Center ranked No. 10 among U.S. cancer centers

Diversity, Equity & Inclusion at Siteman

How Siteman is leading the way in personalized brain tumor treatment

Treatment
Clinical
How Siteman is leading the way in personalized brain tumor treatment
If you or a loved one have recently been diagnosed with a brain tumor, you likely feel a great deal of fear and have many questions. The brain is the epicenter of who we are,...
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How Siteman is leading the way in personalized brain tumor treatment

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The Siteman Approach

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Siteman Cancer Center expands proton therapy treatment

Siteman Cancer Center expands proton therapy treatment

Siteman explains what every woman should know about endometrial cancer risk, symptoms and screening

Siteman explains what every woman should know about endometrial cancer risk, symptoms and screening

Immunity boosting treatment enhances CAR-T cell therapy for blood cancers

Immunity boosting treatment enhances CAR-T cell therapy for blood cancers

$5.3 million grant supports research into lung cancer recurrence

$5.3 million grant supports research into lung cancer recurrence

Couple honors physician with gift for distinguished professorship

Couple honors physician with gift for distinguished professorship

Amit Pathak, PhD

Primary Academic Title

Research Interest

Education

Training

Selected Research Publications