Gary J. Patti, PhD

Gary J. Patti, PhD

Primary Academic Title

Professor of Chemistry and of Genetics and Medicine, Michael and Tana Powell Professor of Chemistry, Washington University School of Medicine

Research Interest

We are interested in using advanced metabolic technologies to quantitatively cancer metabolism.

Education

  • 2008: PhD, chemistry, Washington University, St. Louis

Training

  • 2008 - 2011: NIH postdoctoral fellow, The Scripps Research Institute, La Jolla, Calif.

Selected Research Publications

Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish.
  • Huang D, Kapadia EH, Liang Y, [...] Patti GJ, [...] Parichy DM
  • Proc Natl Acad Sci USA 2025
Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer.
  • Fowle-Grider R, Rowles JL, Shen I, [...] Patti GJ
  • Nature 2024
Metabolite signatures of chronological age, aging, survival, and longevity.
  • Sebastiani P, Monti S, Lustgarten MS, [...] Patti GJ
  • Cell Rep 2024
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer.
  • Buglakova E, Ekelöf M, Schwaiger-Haber M, [...] Patti GJ, [...] Alexandrov T
  • Nat Metab 2024
MPI-VGAE: protein-metabolite enzymatic reaction link learning by variational graph autoencoders.
  • Wang C, Yuan C, Wang Y, [...] Patti GJ, [...] Hou Q
  • Brief Bioinformatics 2023
Cytosolic and mitochondrial NADPH fluxes are independently regulated.
  • Niu X, Stancliffe E, Gelman SJ, [...] Patti GJ
  • Nat Chem Biol 2023
Uridine-derived ribose fuels glucose-restricted pancreatic cancer.
  • Nwosu ZC, Ward MH, Sajjakulnukit P, [...] Patti GJ, [...] Lyssiotis CA
  • Nature 2023
Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem.
  • Schwaiger-Haber M, Stancliffe E, Anbukumar DS, [...] Patti GJ
  • Nat Commun 2023
Monounsaturated and Diunsaturated Fatty Acids Sensitize Cervical Cancer to Radiation Therapy.
  • Muhammad N, Ruiz F, Stanley J, [...] Patti GJ, Schwarz JK
  • Cancer Res 2022
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells.
  • Wang Y, Stancliffe E, Fowle-Grider R, [...] Patti GJ
  • Mol Cell 2022
MYC sensitises cells to apoptosis by driving energetic demand.
  • Edwards-Hicks J, Su H, Mangolini M, [...] Patti GJ, [...] Finch AJ
  • Nat Commun 2022
A multidimensional metabolomics workflow to image biodistribution and evaluate pharmacodynamics in adult zebrafish.
  • Jackstadt MM, Chamberlain CA, Doonan SR, Shriver LP, Patti GJ
  • Dis Model Mech 2022