Gary J. Patti, PhD

Gary J. Patti, PhD

Primary Academic Title

Professor of Chemistry and of Genetics and Medicine, Michael and Tana Powell Professor of Chemistry, Washington University School of Medicine

Research Interest

We are interested in using advanced metabolic technologies to quantitatively cancer metabolism.

Education

  • 2008: PhD, chemistry, Washington University, St. Louis

Training

  • 2008 - 2011: NIH postdoctoral fellow, The Scripps Research Institute, La Jolla, Calif.

Selected Research Publications

Decoding cancer across scales with metabolomics.
  • Rowles JL, Patti GJ
  • Nat Rev Cancer 2026
Intestine-derived sorbitol drives steatotic liver disease in the absence of gut bacteria.
  • Jackstadt MM, Fowle-Grider R, Song MG, [...] Patti GJ
  • Sci Signal 2025
Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer.
  • Fowle-Grider R, Rowles JL, Shen I, [...] Patti GJ
  • Nature 2024
Metabolite signatures of chronological age, aging, survival, and longevity.
  • Sebastiani P, Monti S, Lustgarten MS, [...] Patti GJ
  • Cell Rep 2024
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer.
  • Buglakova E, Ekelöf M, Schwaiger-Haber M, [...] Patti GJ, [...] Alexandrov T
  • Nat Metab 2024
Cytosolic and mitochondrial NADPH fluxes are independently regulated.
  • Niu X, Stancliffe E, Gelman SJ, [...] Patti GJ
  • Nat Chem Biol 2023