Jacqueline Payton, MD, PhD

Jacqueline Payton, MD, PhD

Primary Academic Title

Associate Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine

Research Interest

Epigenetic alterations and gene regulation in cancer and infection, genomic analyses of cancer, epigenetic mechanisms of cancer progression and therapy resistance, lymphomas and leukemias


  • 2002: PhD, molecular and cellular biology, University of Illinois, Urbana
  • 2004: MD, University of Illinois, Urbana


  • 2004 - 2008: Resident, pathology, Washington University, St. Louis
  • 2006 - 2007: Clinical fellow, internal medicine, Washington University

Selected Research Publications

Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation.
  • Cubitt CC, Wong P, Dorando HK, [...] Payton JE, Fehniger TA
  • J Clin Invest 2024
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia.
  • Kramer MH, Zhang Q, Sprung R, [...] Payton JE, [...] Ley TJ
  • Blood 2022
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.
  • Wilson ER, Helton NM, Heath SE, [...] Payton JE, [...] Spencer DH
  • Leukemia 2022
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
  • Ferraro F, Miller CA, Christensen KA, [...] Payton JE, [...] Ley TJ
  • Proc Natl Acad Sci USA 2021
Determining subpopulation methylation profiles from bisulfite sequencing data of heterogeneous samples using DXM.
  • Fong J, Gardner JR, Andrews JM, [...] Payton JE, [...] Edwards JR
  • Nucleic Acids Res 2021
Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers.
  • Andrews JM, Pyfrom SC, Schmidt JA, [...] Payton JE
  • EBioMedicine 2021

View All Publications