Premal Thaker, MD, MS

Premal Thaker, MD, MS

Gynecologic Oncology, Surgeon

Primary Academic Title

David G. and Lynn Mutch Distinguished Professor of Obstetrics and Gynecology; Director, Gynecological Oncology Clinical Research; Chief, Division of Gynecologic Oncology

Clinical Expertise

As a member of our ovarian, cervical and endometrial cancer specialist teams, Dr. Thaker cares for patients diagnosed with these cancers through treatment and recovery.

Research Interest

Biobehavioral influences on cancer development and therapy in gynecologic malignancies.

Education

  • 1997: MD, Medical College of Pennsylvania, Philadelphia
  • 2004: MS, Cancer Biology, University of Texas Graduate School of Biomedical Sciences, Houston

Training

  • 1997 - 1999: Intern and resident, obstetrics and gynecology, Allegheny University Hospital-City Avenue, Philadelphia
  • 1999 - 2002: Resident, obstetrics and gynecology, University of Pennsylvania, Philadelphia
  • 2002 - 2006: Fellow, gynecologic oncology, University of Texas M.D. Anderson Cancer Center, Houston

Selected Research Publications

Potential of IMNN-001 in epithelial ovarian cancer: assessment of clinical findings.
  • Thaker PH, Lindborg SR, Limon A, [...] Alvarez RD
  • Expert Opin Investig Drugs 2026
Efficacy and Safety of Avutometinib ± Defactinib in Recurrent Low-Grade Serous Ovarian Cancer: Primary Analysis of ENGOT-OV60/GOG-3052/RAMP 201.
  • Banerjee SN, Van Nieuwenhuysen E, Aghajanian C, [...] Thaker PH, [...] Grisham RN
  • J Clin Oncol 2025
Phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer.
  • Schab A, Compadre A, Drexler R, [...] Thaker P, [...] Mullen MM
  • J Clin Invest 2025
Quality of life and survivorship in patients with low-grade ovarian cancer.
  • Lemieux M, Telles R, Goodheart M, [...] Thaker PH
  • Gynecol Oncol 2024
NCCN Guidelines® Insights: Ovarian Cancer/Fallopian Tube Cancer/Primary Peritoneal Cancer, Version 3.2024.
  • Liu J, Berchuck A, Backes FJ, [...] Thaker PH, [...] Armstrong DK
  • J Natl Compr Canc Netw 2024
Phase II Study of Olaparib and Temozolomide for Advanced Uterine Leiomyosarcoma (NCI Protocol 10250).
  • Ingham M, Allred JB, Chen L, [...] Thaker PH, [...] Schwartz GK
  • J Clin Oncol 2023
RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer.
  • Compadre AJ, van Biljon LN, Valentine MC, [...] Thaker PH, [...] Mullen MM
  • Clin Cancer Res 2023

Contact Information

  • Center for Advanced Medicine at Siteman Cancer Center

    4921 Parkview Place
    Saint Louis, MO 63110

Phone Numbers

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