Premal Thaker, MD, MS

Premal Thaker, MD, MS

Gynecologic Oncology, Surgeon

Primary Academic Title

David G. and Lynn Mutch Distinguished Professor of Obstetrics and Gynecology; Director, Gynecological Oncology Clinical Research; Interim Chief, Division of Gynecologic Oncology

Clinical Expertise

As a member of our ovarian, cervical and endometrial cancer specialist teams, Dr. Thaker cares for patients diagnosed with these cancers through treatment and recovery.

Research Interest

Biobehavioral influences on cancer development and therapy in gynecologic malignancies.


  • 1997: MD, Medical College of Pennsylvania, Philadelphia
  • 2004: MS, Cancer Biology, University of Texas Graduate School of Biomedical Sciences, Houston


  • 1997 - 1999: Intern and resident, obstetrics and gynecology, Allegheny University Hospital-City Avenue, Philadelphia
  • 1999 - 2002: Resident, obstetrics and gynecology, University of Pennsylvania, Philadelphia
  • 2002 - 2006: Fellow, gynecologic oncology, University of Texas M.D. Anderson Cancer Center, Houston

Selected Research Publications

The biology of hope: Inflammatory and neuroendocrine profiles in ovarian cancer patients.
  • Lutgendorf SK, Telles RM, Whitney B, Thaker PH, [...] Corn BW
  • Brain Behav Immun 2024
In situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy.
  • Corvigno S, Badal S, Spradlin ML, [...] Thaker PH, [...] Sood AK
  • NPJ Precis Oncol 2023
Phase II Study of Olaparib and Temozolomide for Advanced Uterine Leiomyosarcoma (NCI Protocol 10250).
  • Ingham M, Allred JB, Chen L, [...] Thaker PH, [...] Schwartz GK
  • J Clin Oncol 2023
RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer.
  • Compadre AJ, van Biljon LN, Valentine MC, [...] Thaker PH, [...] Mullen MM
  • Clin Cancer Res 2023
Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer.
  • Eskander RN, Sill MW, Beffa L, [...] Thaker PH, [...] Aghajanian C
  • N Engl J Med 2023
Propranolol reduces IFN-γ driven PD-L1 immunosuppression and improves anti-tumour immunity in ovarian cancer.
  • Falcinelli M, Al-Hity G, Baron S, [...] Thaker PH, Flint MS
  • Brain Behav Immun 2023
NCCN Guidelines® Insights: Ovarian Cancer, Version 3.2022.
  • Armstrong DK, Alvarez RD, Backes FJ, [...] Thaker PH, [...] Hang L
  • J Natl Compr Canc Netw 2022

Contact Information

  • Washington University Medical Campus

    4921 Parkview Place
    Saint Louis, MO 63110

Phone Numbers

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