Sidharth V. Puram, MD, PhD

Surgeon

Primary Academic Title

Associate Professor of Otolaryngology, Division of Head and Neck Surgery, Washington University School of Medicine

Clinical Expertise

Head and neck surgery

Research Interest

Tumor heterogeneity in head and neck cancer and its implications for prognosis, treatment response, and underlying biology, head and neck squamous carcinoma, additional interests include salivary malignancies

Education

2013: MD, Harvard Medical School - MIT Health Sciences and Technology
2011: PhD, pathology, Harvard Medical School

Training

2013 - 2014: Intern, general surgery, Massachusetts General Hospital, Boston
2014 - 2017: Resident, otolaryngology, Harvard Combined Program in Otolaryngology
2017 - 2018: Chief resident, otolaryngology, Harvard Combined Program in Otolaryngology
2018 - 2019: Fellow, head and neck oncology, Ohio State University, Columbus

Board Certification

2019: American Board of Otolaryngology (in review)

Selected Research Publications

Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state.

Barrett TF, Patel B, Khan SM, [...] Puram SV, Kim AH
Nat Commun 2024

Patient Navigation for Timely, Guideline-Adherent Adjuvant Therapy for Head and Neck Cancer: A National Landscape Analysis.

Graboyes EM, Chappell M, Duckett KA, [...] Puram SV, [...] Calhoun E
J Natl Compr Canc Netw 2023

Epigenetic regulation during cancer transitions across 11 tumour types.

Terekhanova NV, Karpova A, Liang WW, [...] Puram SV, [...] Ding L
Nature 2023

Outcomes of Cranioplasty Reconstructions: Review of Cranioplasty Implants and Free Flap Coverage Variables that Affect Implant Exposure.

Slijepcevic AA, Scott B, Lilly GL, [...] Puram S
Laryngoscope Investig Otolaryngol 2023

Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer.

Jacobs MT, Wong P, Zhou AY, [...] Puram SV, Fehniger TA
Clin Cancer Res 2023

Immune Cell Deconvolution Reveals Possible Association of γδ T Cells with Poor Survival in Head and Neck Squamous Cell Carcinoma.

Parikh AS, Li Y, Mazul A, [...] Puram SV
Cancers (Basel) 2023

Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer.

Oliveira G, Egloff AM, Afeyan AB, [...] Puram SV, [...] Uppaluri R
Sci Immunol 2023

Margins in Stage I and II Oral Cavity Squamous Cell Carcinoma: A Review From the American Head and Neck Society.

Puram SV, Mays AC, Bayon R, [...] Varvares MA
JAMA Otolaryngol Head Neck Surg 2023

Epigenetic regulation of hybrid epithelial-mesenchymal cell states in cancer.

Sample RA, Nogueira MF, Mitra RD, Puram SV
Oncogene 2023

Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours.

Gavish A, Tyler M, Greenwald AC, [...] Puram SV, Tirosh I
Nature 2023

Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma.

Puram SV, Mints M, Pal A, [...] Tirosh I
Nat Genet 2023

Changing Epidemiology of Oral Cavity Cancer in the United States.

Stepan KO, Mazul AL, Larson J, [...] Puram SV
Otolaryngol Head Neck Surg 2023

Single-cell RNA sequencing identifies a paracrine interaction that may drive oncogenic notch signaling in human adenoid cystic carcinoma.

Parikh AS, Wizel A, Davis D, [...] Puram SV
Cell Rep 2022

RNA sequencing and expression heterogeneity in head and neck cancer.

Parikh AS, Puram SV
Cancer Cytopathol 2022

Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer.

Cui Zhou D, Jayasinghe RG, Chen S, [...] Puram SV, [...] Ding L
Nat Genet 2022

View All Publications

Contact Information

Washington University Medical Campus

4921 Parkview Place
Saint Louis, MO 63110

Phone Numbers

Appointments: (800) 600-3606
Toll Free: (314) 747-7222

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