Regis James O'Keefe, MD, PhD

Regis James O'Keefe, MD, PhD

Orthopaedic Surgeon, Surgeon

Primary Academic Title

Chairman, Department of Orthopaedic Surgery, Fred C. Reynolds Professor of Orthopaedic Surgery, Washington University School of Medicine

Clinical Expertise

As a member of our sarcoma specialist team, Dr. O’Keefe cares for patients diagnosed with sarcomas and rare tumors through treatment and recovery. Learn more about how Dr. O’Keefe and Siteman approach extremity and non-extremity sarcoma treatment and recovery.

Research Interest

Clinical interests include the management of benign and malignant bone and soft (connective) tissue tumors in both children and adults, bone infections, skeletal reconstruction, curettage of bone tumors and allograft procedures. Research interests include cartilage research, bone repair, skeletal development, cancer and inflammatory diseases of bone.


  • 1985: MD, Harvard University, Boston
  • 2000: PhD, Biochemistry and Biophysics, University of Rochester, Rochester, N.Y.


  • 1985 - 1986: Intern, surgery, New England Deaconess Hospital, Harvard University, Boston
  • 1986 - 1988: Instructor and fellow, orthopaedic research, University of Rochester, Rochester, N.Y.
  • 1988 - 1992: Resident, orthopaedics, University of Rochester
  • 1992 - 1993: Fellow, orthopaedic oncology, Massachusetts General Hospital, Boston

Board Certification

  • 1996: American Board of Orthopaedic Surgery

Selected Research Publications

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Contact Information

  • Washington University Medical Campus

    4921 Parkview Place
    Saint Louis, MO 63110

Phone Numbers

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