Buck Rogers, PhD

Buck Rogers, PhD

Primary Academic Title

Professor of Radiation Oncology, Division of Radiation and Cancer Biology, Washington University School of Medicine

Research Interest

My research focuses on molecular imaging and targeted radiotherapy. Utilization of radioactive peptides that bind to tumor-selective receptors has advantages for both of these applications. My group has evaluated peptides that bind to the G-coupled protein receptors, gastrin-releasing peptide receptor (GRPR) and somatostatin receptor subtype 2 (SSTR2). We have also used somatostatin analogues to image SSTR2 after gene transfer with adenoviral vector encoding for SSTR2 (AdSSTR2).

Education

  • 1991: MA, chemistry, Washington University, St. Louis
  • 1995: PhD, inorganic chemistry, Washington University

Selected Research Publications

Beyond Average: α-Particle Distribution and Dose Heterogeneity in Bone Metastatic Prostate Cancer.
  • Benabdallah N, Lu P, Abou DS, [...] Rogers BE, [...] Thorek DLJ
  • J Nucl Med 2024
Development of a [89Zr]Zr-labeled human antibody using a novel phage-displayed human scFv library.
  • Singh AK, Lewis CD, Boas CAWV, [...] Rogers BE, [...] Hallahan DE
  • Clin Cancer Res 2024
Preclinical Efficacy of a PARP-1 Targeted Auger-Emitting Radionuclide in Prostate Cancer.
  • Sreekumar S, Zhou D, Mpoy C, [...] Rogers BE
  • Int J Mol Sci 2023
First-in-Humans Evaluation of Safety and Dosimetry of 64Cu-LLP2A for PET Imaging.
  • Laforest R, Ghai A, Fraum TJ, [...] Rogers BE, [...] Dehdashti F
  • J Nucl Med 2023
Copper-67-Labeled Bombesin Peptide for Targeted Radionuclide Therapy of Prostate Cancer.
  • Huynh TT, van Dam EM, Sreekumar S, [...] Rogers BE
  • Pharmaceuticals (Basel) 2022
Therapeutic Efficacy of 177Lu-Labeled A20FMDV2 Peptides Targeting ανβ6.
  • Huynh TT, Sreekumar S, Mpoy C, Rogers BE
  • Pharmaceuticals (Basel) 2022
Radiation-induced neoantigens broaden the immunotherapeutic window of cancers with low mutational loads.
  • Lussier DM, Alspach E, Ward JP, [...] Rogers BE, Schreiber RD
  • Proc Natl Acad Sci USA 2021

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